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    Home > Active Ingredient News > Blood System > Nat Commun: 17 prospective studies reveal that blood n-3 fatty acid levels are associated with reduced all-cause mortality

    Nat Commun: 17 prospective studies reveal that blood n-3 fatty acid levels are associated with reduced all-cause mortality

    • Last Update: 2021-05-08
    • Source: Internet
    • Author: User
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    Since researchers reported the inverse relationship between n-3 polyunsaturated fatty acids (PUFA) and the risk of acute myocardial infarction in the Greenland Eskimos in the 1970s , the n-3 polyunsaturated fatty acids (PUFA) family has been The object of scientific research.
    PUFAs in this family include 18-carbon plant-derived α-linolenic acid (ALA), and 20-22 carbon long-chain (LC, mainly derived from seafood) eicosapentaenoic acid (EPA) and docosa-two carbon Pentaenoic acid (DPA) and docosahexaenoic acid (DHA).

    Myocardial infarction

    LC n-3 PUFAs in reducing medsci.
    cn/course/search.
    do?w=%E5%BF%83%E8%A1%80%E7%AE%A1">cardiac vascular efficacy disease (CVD) risk remains controversial, because different randomized controlled trials (RCTs) are found to be contradictory.
    A 2019 RCT meta-analysis reported that among patients randomly supplemented with LC n-3 PUFAs, the risks of myocardial infarction, coronary heart disease (CHD) events and mortality, and CVD mortality were significantly reduced.
    A meta-analysis of another observational study found that higher circulating LC n-3 PUFA levels were significantly associated with a lower risk of CHD death.
    However, there has not been a meta-analysis to study the relationship between the blood level of LC n-3 PUFAs and the risk of all-cause mortality.

    medsci.
    cn/course/search.
    do?w=%E5%BF%83%E8%A1%80%E7%AE%A1">Heart blood vessels

    Recently, researchers reported the results of a new ensemble analysis from 17 prospective cohort studies that studied the relationship between blood omega-3 fatty acid levels and the risk of all-cause mortality.
    During the 16-year follow-up, 15,720 of the 42,466 people included in the study died.

    During the 16-year follow-up, 15,720 of the 42,466 people included in the study died.
    During the 16-year follow-up, 15,720 of the 42,466 people included in the study died.

    Researchers found that after multivariate adjustments for related risk factors, circulating long-chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid) Compared with the lowest quintile, the risk of death from all causes is significantly reduced (15-18%, at least p <0.
    003)
    in the highest quintile of enoic acid .

    The highest and lowest quintiles of circulating long chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid) In comparison, the risk of death from all causes is significantly reduced in circulating long-chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid) The highest quintile compared with the lowest quintile, the risk of death from all causes is significantly reduced

    Adjusted hazard ratios of circulating eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) to total mortality (HR, 95% CI)

    Adjusted hazard ratios of circulating eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) to total mortality (HR, 95% CI)

    In addition, researchers have also found similar relationships with deaths caused by cardiovascular disease, cancer, and other causes.
    However, the researchers
    did not find a relationship with the 18-carbon omega-3, alpha-linolenic acid.

    No relationship with 18-carbon omega-3, alpha-linolenic acid has been found.
    No relationship with 18-carbon omega-3, alpha-linolenic acid has been found.

    These findings indicate that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.

    Higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.
    Higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.

     

    Original source:

    Original source:

    William S.
    Harris et al.
    Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies.
    Nat Commun (2 021) .
     

    William S.
    Harris et al.
    Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies.
    Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies.
    Nat Commun (2 021 )  

     

     



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