Nat Commun: Clinical trials have confirmed that the natural product berberine regulates insulin secretion and treats diabetes

Natural plants are a rich source of new drugs

Natural plants are a rich source of new drugs

Recently, researchers reported on the effect of berberine (BBR) on stimulating insulin secretion

Recently, researchers reported on the effect of berberine (BBR) on stimulating insulin secretion

Further studies have shown that BBR directly binds to KCNH6 potassium channels, significantly accelerating channel closure and subsequently reducing KCNH6 currents

Berberine increases the secretion of highly glucose-dependent insulin

Berberine increases the secretion of high glucose-dependent insulin Berberine increases the secretion of high glucose-dependent insulin

Finally, in order to evaluate the effect of BBR on human insulin secretion, the researchers conducted a randomized, double-blind, placebo-controlled, two-phase crossover, single-dose Phase 1 clinical trial (NCT03972215), which included 15 healthy men who received 160 minutes hyperglycemia clamp experiment

Finally, in order to evaluate the effect of BBR on human insulin secretion, the researchers conducted a randomized, double-blind, placebo-controlled, two-phase crossover, single-dose Phase 1 clinical trial (NCT03972215), which included 15 healthy men who received 160 minutes hyperglycemia clamp experiment

The results show that, compared with placebo treatment, BBR can significantly promote insulin secretion in a hyperglycemic state without affecting the body's basal insulin secretion

Thus, in this study, researchers found that a BBR for glucose-dependent insulin secretagogue KCNH6 channels, for the treatment of diabetes without causing hypoglycemia

Original source:

Original source: Original source:

Miao-Miao Zhao et al.

Miao-Miao Zhao et al.

 

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