Nat Commun: Monitoring RNA hot spots or susceptible targets that can reveal cancer cells is expected to help develop new targeted anti-cancer therapies

, June 16, 2020 /PRNewswire
/ -- In a recent study published in the international journal
nature communications, scientists from the University of California and other institutions have revealed a special protein responsible forgeneticchanges or can lead to multiple cancers, and the results may help develop effective targeted cancer therapiesIn the article, the researchers reveal how genomic instability induced by the APOBEC3A protein provides an unknown susceptibility in cancer cellsPicture Source: UCI School of Medicine
In human cells, thousands of DNA damage occurs every day in cancer cells, and in cancer cells, the expression of the protein APOBEC3A is one of the most common sources of DNA damage and mutations that causetumorsevolve when they occur, which may cause DNA to break, resulting in an susceptibility/vulnerabilityresearcher DrRemi Buisson said that targeting cancer cells that carry high levels of APOBEC3A protein activity while interfering with the DNA damage that is necessary to repair damage caused by the APOBEC3A protein may be key
to developing more effective cancer therapies;To understand the key role of the APOBEC3A protein in tumor evolution and to target the susceptibility of APOBEC3A protein-induced, researchers developed a new detection method to determine the activity of THE APOBEC3A protein edited by RNA in cancer cells; It is difficult to quantify, so it is very important to develop a highly sensitive method to determine the activity of the protein, using the hot RNA mutation information identified from a PositiveTumorfrom APOBEC3A, the researchers developed a new detection method based on the digital PCR of microdrops, and proved the applicability of the technique in clinical samples of cancer patients the final researcher Buisson said, this paper proposes a new strategy to track the disorder of aPOBEC3A protein in tumors, thus providing an opportunity to investigate aPOBEC3A's role in tumor evolution and the therapeutic susceptibility of APOBEC3A-induced treatment The researchers hope that using RNA-based APOBEC3A testing may significantly improve understanding of protein function during the of tumors, while also helping them to develop new targeted anticancer therapies effectively using the weaknesses of cancer cells (BioValleyBioon.com) original origins: Jalili, P., Bowen, D., Langenbucher, A et al.
Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots .
Nat Commun 11, 2971 (2020) doi: 10.1038/s41467-020-16802-8