Nat Commun: The calcium signaling of T cells in patients with peanut trenneic acid regulation rheumatoid arthritis promotes the occurrence of glioblastitis

Rheumatoid arthritis (RA) and psoriasis arthritis (PsA) are systemic autoimmune diseases that manifest themselves as chronic glioarthritis, which can lead to damage to joint structure.
PsA occurs in the environment of psoriasis, an autoimmune skin disease characterized by excessive rapid growth of the skin cortical layer due to skin inflammation.
common to both diseases is that abnormal reactions in CD4-T cells are associated with the pathogenesis of the disease.
previous studies have shown that many of RA's genetic susceptibility factors are related to the function of T cells, and that PsA's disease susceptibility genes are often involved in the biological function of T cells.
the differentiation of T-cells has been found in RA and PSA, it is not clear the molecular mechanisms associated with promoting self-reactive T-cell activation.
in the study, the researchers found that the expression levels of the calcium channel protein ORAI3 increased in CD4-T cells in RA and PSA patients, improving the activity of the calcium selective channel (ARC) and making T-cells sensitive to peanut tyrene.
a similar increase in expression in T-cells in patients with systemic lupus erythematosus.
further studies have shown that the increase in ORAI3 transcription levels in RA and PSA T cells is caused by a decrease in the expression of IKAROS, which is the deterrent factor for ORAI3 promoter transcription.
the activation of the ARC channel by peanut tyrenoleic acid can not only cause calcium inflow, but also cause phosphate of proteins associated with the transcatalytic reaction of T-cell-like sensor signals.
Peanut trenic acid activates T cells by mediated ORAI3 in a human membrane-embedded mouse model, and silence from ORAI3 in the over-metastasis T cells of RA patients reduces the inflammatory response of tissues, while reducing the expression level of IKAROS in the supersecond T cells from healthy individuals induces styling.
, the study found that reduced IKAROS expression levels induced by increased ARC activity made T cells more reactive and ultimately led to chronic inflammation in RA and PSA.