Nat Commun: The study found that the lipoprotein J-LRP2 axis is at the heart of maintaining normal glucose balance and insulin sensitivity.

Crosstalk between the liver and skeletal muscles is essential for glucose stability.
liver factors, liver-derived proteins, play an important role in regulating muscle metabolism and are important for this crosstalk.
this study, we found that lipoprotein J (ApoJ) is a new type of liver factor that is cascaded with insulin lipolyst (IR) signaling through the LDL-related protein-2 (LRP2) dependence mechanism, targeting muscle glucose metabolism and insulin sensitivity.
in muscles, LRP2 is necessary for insulin-dependent IR internalization and is the initial trigger for insulin signal transduce, which is essential for regulating downstream signal transductivity and glucose intake.
physiologically, the absence of liver ApoJ or muscle LRP2 can lead to insulin resistance and glucose insatiability.
in patients with polycystic ovary syndrome and insulin resistance, improvements in insulin action induced by pyridoxine were associated with increased expression of muscle ApoJ and LRP2.
, the lipoprotein J-LRP2 axis is a new endocrine circuit that is at the heart of maintaining normal glucose balance and insulin sensitivity.
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