Nat Genet: What's new! The intestinal bacteria and blood type are regulated by the same gene, and enteritis may be related to your blood type

The human intestine is full of a large number of microorganisms, this group of microorganisms rely on the human gut supply of nutritional life, while helping the human body to complete a variety of physiological and bio-chemical functions.
as an important place for human digestion and absorption and the largest immune organ, its internal large microbial population plays a vital role in human health.
years, scientists around the world have been exploring the effects of microbes on human health.
previous studies of twins have shown that genetics is a key factor affecting the composition of the microbiome in the body, but how it affects the composition of microbes in the gut remains unsoly explained.
recently, a team at the University of Kiel in Germany published an article in the journal Nature Genetics entitled "Genome-wide association study in 8,956 German individuals influence the ABO histo-blood groups on gut microbiome", identifying for the first time that genetics in the human genome affect the composition of gut microbes, and even more magically, genes that regulate blood type also regulate the composition of microbes in the gut.
researchers selected nearly 9,000 subjects from three regions of Germany, divided into five groups, and compared age, sex and BMI (body mass index) with the intestinal bacteriomes of the subjects, and showed that the gut microbiomes in each group were similar to each group, with the same core microbiome.
group of subjects' gut microbiome statistics, the researchers performed bio-informational analysis of the subjects' genome-wide, gut microbial and Mendelian randomization data, which showed that host genetic variations may affect the composition of the gut bacterigroup and identified 44 genome-wide significant associations involving microbial characteristics and community composition, involving a total of 38 genomic bits.
the genetic site, which is significantly associated with the ABO blood type gene, was pleasantly associated with two of the gene site.
one is the point at which faecal (Faecalibacterium sp.) OTU99-16 is regulated, and the other is the point at which Bacteroids OTU97-27 is regulated, indicating a link between the ABO blood type and the gut microbiome.
The two genetic points associated with regulating blood type biology generally recognize that ABO blood types are divided into A, B, AB and O types, which contain a small amount of H antigen on red blood cells, of which only a small amount of H antigen on red blood cells of type O blood.
and FUT2 is called a "secretion gene" and is associated with the secretion of H antigens on the surface of blood cells, if FUT2 is infused due to mutations, blood cells do not secrete H antigens.
Four blood type formation patterns chart to further explore the relationship between ABO blood type and gut microorganisms, the researchers analyzed the link between FUT2 and Bacillus, the results show that fuT2 secretion and the abundance of Bacillus is positively related, in simple terms, in A, B and AB blood type people, the presence of more bacillus groups.
previous studies have shown that Bacillus OTU97_27 is associated with inflammatory bowel disease (IBD), which further illustrates the increased prevalence of IBD in people of blood type A, B and AB. "We made an interesting observation based on human genetic factors, and for some people, the "secretions" produced by their red blood cells may be a source of energy for a particular bacterus, thereby promoting the growth of specific microorganisms in the gut," said lead author Dr. Rühlemann, lead author of the paper on the effects of
FUT2 on gut microbiomes.
overall, the study bridges the gap between genetics and the composition of gut microbes, and provides more genetic explanations for intestinal diseases, which may be treated from a blood type perspective in the future.