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Nat Med: Analysis of the efficacy of dual targeting CART cells in children and young adults with relapsed or refractory B-ALL

 Last Update: 2021-10-20
 Source: Internet
 Author: User

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Chimeric antigen receptor (CAR) T cells targeting CD19 or CD22 have significant activity in the treatment of B-cell acute lymphoblastic leukemia (B-ALL)

Recently, a research article was published in the top medical journal Nature Medicine.

child

The primary endpoint of the study is the incidence of grade 3-5 toxic events during dose-limiting toxicity and the frequency of dose-limiting toxicity events.

AUTO3 has good safety, and there is no case report of dose-limiting toxicity or serious cytokine release syndrome or neurotoxicity related to AUTO3

The recurrence may be due to the limited durability of long-term AUTO3

Original source:

Shaun Cordoba,et al.

CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial

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