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Nat Med: Axicabtagene ciloleucel as first-line treatment for high-risk large B-cell lymphoma

 Last Update: 2022-04-24
 Source: Internet
 Author: User

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Large B-cell lymphoma (LBCL) accounts for around 40% of all new diagnoses of non-Hodgkin lymphoma worldwide, making it the most common subtype
.

Approximately 60 % of patients with LBCL have a durable response to standard first-line chemoimmunotherapy regimens such as 6 cycles of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) or Dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (DA-EPOCH-R)

In this phase 2, multicenter, single-arm ZUMA-12 study (Clinical Trials.
gov NCT03761056), investigators evaluated CAR-Follicular Lymphoma T-cell therapy Axicabtagene Ciloleucel (Axi-Cel), an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, in first-line therapy in 40 high-risk LBCL patients
.

The primary outcome of the trial was complete response rate (CRR), and secondary outcomes were objective response rate (ORR), duration of response (DOR), event-free survival (EFS), progression-free survival (PFS), overall survival (OS), safety assessment, central nervous system (CNS) recurrence, CART cells and cytokine levels in blood
.

The primary endpoint was met in patients evaluable for efficacy (n = 37) with a CRR of 78% (95% confidence interval (CI) 62-90) and an ORR of 89% (95% CI 75-97)
.

As of May 17, 2021 (median follow-up, 15.

It can be seen that Axi-Cel is very effective as a first-line treatment for high-risk LBCL patients, and has a controllable safety profile
.

Axi-Cel is very effective as a first-line treatment for high-risk LBCL patients with a manageable safety profile
.

Original source:

Sattva S.

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