Nat Med: Offspring of people with inflammatory colitis are predisposed to autism

Autism spectrum disorder (autism) is a chronic neurodevelopmental disorder with a highly variable clinical presentation

Crohn's disease and UC are major subtypes of inflammatory bowel disease (IBD), a chronic disease

Christina Dardani's research team at the University of Bristol in the United Kingdom publishes important research in

The study conducted 4 complementary studies to investigate the association between parental IBD and autism in children and to elucidate its underlying causes

(1) In a national cohort in Sweden, the association between parent-diagnosed IBD and autism in children;

(2) Genetic correlation between IBD and autism was analyzed using genome-wide association study (GWAS) for aggregate statistics;

(3) In a large UK birth cohort, there is a polygenic association between the maternal genetic predisposition to IBD and the child's autistic traits;

(4) The potential causality and reverse causality of genetic susceptibility to IBD to autism using bidirectional two-sample Mendelian randomization (MR) was

Table 2.

Table 3.

A multi-gene risk score analysis of longitudinal studies of parents and children showed an association

Table 4.

Mendelian randomization analysis of two samples demonstrated the potential causal effect

Table 5 Mendelian randomized IVW assesses the effects of genetic predisposition to autism in IBD, Crohn's disease, and UC, and vice versa

Linkage imbalance score regression did not show a genetic correlation

A triangulation of the evidence from these four complementary approaches revealed evidence

Original source

Parental inflammatory bowel disease and autism in children.