Nat Microbiol: Scientists hope to use a combination of phage and antibiotic therapy to treat infections caused by the superbug Bosco!

January 19, 2021 // -- One of the major health risks of hospitalization is bacterial infection, and hospitals, especially those including intensive care units and surgical wards, are "high-risk areas" of bacteria, some of which also develop resistance to antibiotics, known as "superbugs."
of superbugs are difficult to treat and costly to treat, often with fatal consequences for patients.
In a recent study published in the international journal Nature Microbiology, scientists from Monash University and others revealed how to reverse antibiotic resistance to one of the most dangerous superbugs; researchers used bacterial phages, a virus that kills only bacteria and does not harm the human body.
photo source: CC0 Public Domain, researchers studied the superbug, called Acinetobacter baumannii, which accounts for up to 20 percent of infections in intensive care units; researcher Jeremy 'We may be able to use a lot of phages to kill Bacillus baboon, which is resistant to antibiotics, but the bacteria are very clever, and they can quickly become resistant to phages in a way that is resistant to antibiotics, ' says Professor Barr.
researchers shed light on how Bacillus babodium botules are resistant to the phages that attack it, and how the superbugs are resistant to antibiotics.
Botox produces a capsule-like, viscous outer substance that protects it from antibiotics, while the phages used by the researchers are using the same capsule structure as an inlet to enter the bacteria and have a lethal effect.
in an attempt to escape phage damage, Bacillus babodium stops the capsule-like structure so scientists can use antibiotics they've used to kill the superbug.
in this paper, researchers found that at least seven different antibiotics make Bacillus a resensitive, which greatly expands scientists' resources for treating the bacteria, making the superbug less sensitive.
more research is needed before this new therapeutic strategy can be applied to the clinic, and the current results are very encouraging.
'We have found that this phage has good therapeutic effects in mouse trials, and we will continue to optimize the effectiveness of this treatment in the later stages, and later we may be able to use a combination of phage and antibiotics to effectively treat infections caused by Bacillus aureus,' said dr. Godillo Altamirano, a researcher at the end of the study.
() Originals: Gordillo Altamirano, F., Forsyth, J.H., Patwa, R. et al. Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials. Nat Microbiol (2021). doi：10.1038/s41564-020-00830-7