Nature Communications: Fat cells destroy the transformation process of acute lymphoblastic leukemia, which is conducive to tumor survival and persistence

The specific niche adaptation that promotes survival of primary disease and acute lymphoblastic leukemia (ALL) after induction chemotherapy is not yet known
.

Therefore, an article published by a foreign research team in the journal Nature Communications demonstrated the dynamic evolution of bone marrow (BM) fat cells in the pathogenesis and treatment of ALL

The specific niche adaptation that promotes survival of primary disease and acute lymphoblastic leukemia (ALL) after induction chemotherapy is not yet known

FIG FIG 1: 1: Fat niche BM cells in the pathogenesis and treatment of dynamic remodeling ALL adipocytes BM niche dynamic remodeling in the pathogenesis and treatment of ALL

Figure 2: ALL disrupts the function and lineage activation of the adipocyte precursor mesenchymal stromal cell (MSC) population

FIG.
FIG.
2: 2: ALL destroy the adipose precursor cells of mesenchymal stromal cells (MSC) function and lineage population started ALL destroy the adipose precursor cells of mesenchymal stromal cells (MSC) function and lineage start Group

Figure 3: Adipocytes create a tumor suppressor site in B-ALL

Figure 3: Adipocytes create a tumor suppressor site in B-ALL Figure 3: Adipocytes create a tumor suppressor site in B-ALL

Figure 4: Adipocyte niche restricts protein synthesis in ALL through atypical factors

FIG.
FIG.
4: 4: adipocytes niche protein synthesis is limited by the atypical ALL factor adipocytes niche limit protein synthesis by atypical factors in ALL

Its dynamic evolution is from cell exhaustion in the niche of primary leukemia to a completely rebuilt state after induction of remission
.

Functionally, the fat cells trigger niche ALL cell proliferation and cell still to slow the development direction

Its dynamic evolution is from cell exhaustion in the niche of primary leukemia to a completely rebuilt state after induction of remission

The research highlights several important findings

Original source:

Original source:

Heydt, Q.

Heydt, Q.
, Xintaropoulou, C.
, Clear, A.
et al.
et al.
Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence.
Nat Commun Nat Commun 12,12,  5507 (2021).
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