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This article is converted Medicine original, reproduced please indicate the source Author: Yun Introduction: Recently, the Hong Kong Baptist University School of Medicine, Professor Jia Wei published in "Nature Communications" journal, the study found between diabetes and acid pig ’S association.
As early as 2014, scientists from the Swiss Federal Institute of Technology in Lausanne and researchers from Italy and the Netherlands jointly discovered that bile acids can activate a little-known receptor to overcome the loss of fat cells’ sensitivity to insulin.
This mechanism or It can be used to develop a new type of medicine to treat type 2 diabetes.
The results of this research were published in the Journal of Clinical Investigation, entitled "TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation".
This discovery opens up a new way to solve the inflammation of type 2 diabetes.
Molecules that can mimic the effect of bile acid on TGR5 of macrophages can become new anti-obesity drugs and diabetes drugs.
Alessia Perino, the first author of the study, said: "Of course, we don't want to use bile acids to treat diabetes.
We are looking for molecules that can mimic the effects of bile acids.
We have discovered some small molecules that can treat diabetes.
" Recently, Hong Kong Baptist Church Professor Jia Wei from the College of Chinese Medicine of the University published a research article titled "Hyocholic acid species as novel biomarkers for metabolic disorders" in the journal Nature Communications.
The study found the association between hyocholic acid and diabetes.A series of studies conducted by researchers at Hong Kong Baptist University (HKBU) showed that bile acids and their derivatives (collectively referred to as HCAs) are risk indicators for type 2 diabetes.
The powerful effects of HCAs in regulating blood sugar levels and preventing diabetes have also been discovered.
The study used 5 clinical cohorts with 1500+ subjects to verify that HCAs are expected to become biomarkers for postoperative recovery or early prediction of clinical metabolic diseases, and open a window for the development of diabetes drugs.
High concentration of HCAs can protect pigs from diabetes.
Professor Jia Wei Source: Hong Kong Baptist University's "Compendium of Materia Medica" once recorded that the use of porcine bile can treat "thirst" (now called diabetes).
Inspired by this, Professor Jia Wei from the School of Traditional Chinese Medicine of Hong Kong Baptist University led a research team to conduct a series of studies on the role of HCAs in glucose homeostasis and diabetes prevention.
Diabetes is characterized by high blood sugar levels.
The researchers tested 55 people, 32 mice, and 12 pigs.
The study found that the fasting blood sugar level of pigs was significantly lower than that of humans and mice.
Since HCAs account for nearly 80% of porcine bile acids, and the proportions of bile acids in humans and mice are about 2% and 3%, respectively, it is observed that HCAs are negatively correlated with blood glucose levels.
The results show the potential role of HCAs in maintaining stable glucose levels, which explains why pigs eat more and exercise less but rarely develop diabetes.
HCAs are associated with diabetes and metabolic health.
In order to analyze the correlation between HCA levels and human diabetes, the researchers collected data from two large-scale cohort studies, namely the Shanghai Obesity Study and the Shanghai Diabetes Study.
Researchers investigated the serum bile acid profiles of 1107 participants in the "Shanghai Obesity Study" published in 2013.
The obesity study participants were divided into: 585 healthy and thin people, 419 overweight and obese, and 103 overweight and obese patients with type 2 diabetes.
The results showed that the serum HCAs levels of overweight and obese people and obese people with type 2 diabetes were significantly reduced, and there was a significant negative correlation between HCAs and BMI, fasting and postprandial blood glucose, insulin levels, and HOMA-IR.
In another study, the serum bile acids of 132 participants in the Shanghai Diabetes Study were investigated.
Diabetes study participants are divided into: 26 people with normal blood sugar, 30 patients with prediabetes, and 35 patients with new-onset diabetes.
When participating in the study during 1998-2001, their metabolic indicators were healthy (at baseline).
Ten years later, 86 of them had unhealthy metabolism, and the remaining 46 remained healthy.
Analysis shows that compared with healthy people ten years later, those with unhealthy metabolism have significantly lower serum HCAs baseline levels, indicating that HCAs levels are a powerful predictor of metabolic syndrome (such as diabetes).
HCAs regulate blood sugar levels in animals.
Through a series of laboratory experiments, researchers have further studied the mechanism by which HCAs play a key role in regulating blood sugar levels.
In animal model experiments, the researchers inhibited the synthesis of HCAs in a group of pig livers by about 30%, and they found that their blood sugar levels increased by 30% compared to the control group.
The HCAs are then administered to the pigs, and as a result the blood sugar levels of the pigs are reduced.
Another experiment conducted by the researchers looked at the effect of HCAs on glucagon-like peptide-1 (GLP-1).
GLP-1 is a hormone produced by L cells, which is an intestinal endocrine cell that can enhance insulin secretion and lower blood sugar.
HCAs lower blood sugar diagram In a laboratory environment, different types of bile acids (including HCAs) are applied to L cells at different concentration levels.
The results show that, compared with other types of bile acids, high concentrations of 50 micromolar HCAs are the most effective in stimulating GLP-1 secretion.
The research results also show that HCAs regulate blood glucose levels by stimulating the secretion of GLP-1 and thereby regulating the production of insulin.
The potential of HCAs for the prediction and treatment of diabetes "Our research provides evidence of how HCAs regulate blood sugar levels and reveals the mechanism by which
HCAs are achieved at the cellular level.
HCAs can be developed as predictive drugs and new treatments for type 2 diabetes.
"Professor Jia said.
"Because the intestinal flora can regulate the metabolism of HCAs, targeting the intestine instead of the pancreas may be a new strategy for the treatment of diabetes.
We will further study how to regulate the intestinal bacteria to increase the secretion of HCAs in diabetic patients," Jia The professor added.
At present, Professor Jia Wei's team has applied for invention patents and has begun to systematically develop new drug products based on the structure of hyocholic acid to treat metabolic diseases.
Reference materials: [1] https://medicalxpress.
com/news/2021-04-reveals-hyocholic-acids-agents-diabetes.
html [2] 21744-w [3] https://medicalxpress.
com/news/2021-03-gut-microbiome-glucose.
html Note: This article aims to introduce medical research progress and cannot be used as a reference for treatment options.
If you need health guidance, please go to a regular hospital for treatment.
As early as 2014, scientists from the Swiss Federal Institute of Technology in Lausanne and researchers from Italy and the Netherlands jointly discovered that bile acids can activate a little-known receptor to overcome the loss of fat cells’ sensitivity to insulin.
This mechanism or It can be used to develop a new type of medicine to treat type 2 diabetes.
The results of this research were published in the Journal of Clinical Investigation, entitled "TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation".
This discovery opens up a new way to solve the inflammation of type 2 diabetes.
Molecules that can mimic the effect of bile acid on TGR5 of macrophages can become new anti-obesity drugs and diabetes drugs.
Alessia Perino, the first author of the study, said: "Of course, we don't want to use bile acids to treat diabetes.
We are looking for molecules that can mimic the effects of bile acids.
We have discovered some small molecules that can treat diabetes.
" Recently, Hong Kong Baptist Church Professor Jia Wei from the College of Chinese Medicine of the University published a research article titled "Hyocholic acid species as novel biomarkers for metabolic disorders" in the journal Nature Communications.
The study found the association between hyocholic acid and diabetes.A series of studies conducted by researchers at Hong Kong Baptist University (HKBU) showed that bile acids and their derivatives (collectively referred to as HCAs) are risk indicators for type 2 diabetes.
The powerful effects of HCAs in regulating blood sugar levels and preventing diabetes have also been discovered.
The study used 5 clinical cohorts with 1500+ subjects to verify that HCAs are expected to become biomarkers for postoperative recovery or early prediction of clinical metabolic diseases, and open a window for the development of diabetes drugs.
High concentration of HCAs can protect pigs from diabetes.
Professor Jia Wei Source: Hong Kong Baptist University's "Compendium of Materia Medica" once recorded that the use of porcine bile can treat "thirst" (now called diabetes).
Inspired by this, Professor Jia Wei from the School of Traditional Chinese Medicine of Hong Kong Baptist University led a research team to conduct a series of studies on the role of HCAs in glucose homeostasis and diabetes prevention.
Diabetes is characterized by high blood sugar levels.
The researchers tested 55 people, 32 mice, and 12 pigs.
The study found that the fasting blood sugar level of pigs was significantly lower than that of humans and mice.
Since HCAs account for nearly 80% of porcine bile acids, and the proportions of bile acids in humans and mice are about 2% and 3%, respectively, it is observed that HCAs are negatively correlated with blood glucose levels.
The results show the potential role of HCAs in maintaining stable glucose levels, which explains why pigs eat more and exercise less but rarely develop diabetes.
HCAs are associated with diabetes and metabolic health.
In order to analyze the correlation between HCA levels and human diabetes, the researchers collected data from two large-scale cohort studies, namely the Shanghai Obesity Study and the Shanghai Diabetes Study.
Researchers investigated the serum bile acid profiles of 1107 participants in the "Shanghai Obesity Study" published in 2013.
The obesity study participants were divided into: 585 healthy and thin people, 419 overweight and obese, and 103 overweight and obese patients with type 2 diabetes.
The results showed that the serum HCAs levels of overweight and obese people and obese people with type 2 diabetes were significantly reduced, and there was a significant negative correlation between HCAs and BMI, fasting and postprandial blood glucose, insulin levels, and HOMA-IR.
In another study, the serum bile acids of 132 participants in the Shanghai Diabetes Study were investigated.
Diabetes study participants are divided into: 26 people with normal blood sugar, 30 patients with prediabetes, and 35 patients with new-onset diabetes.
When participating in the study during 1998-2001, their metabolic indicators were healthy (at baseline).
Ten years later, 86 of them had unhealthy metabolism, and the remaining 46 remained healthy.
Analysis shows that compared with healthy people ten years later, those with unhealthy metabolism have significantly lower serum HCAs baseline levels, indicating that HCAs levels are a powerful predictor of metabolic syndrome (such as diabetes).
HCAs regulate blood sugar levels in animals.
Through a series of laboratory experiments, researchers have further studied the mechanism by which HCAs play a key role in regulating blood sugar levels.
In animal model experiments, the researchers inhibited the synthesis of HCAs in a group of pig livers by about 30%, and they found that their blood sugar levels increased by 30% compared to the control group.
The HCAs are then administered to the pigs, and as a result the blood sugar levels of the pigs are reduced.
Another experiment conducted by the researchers looked at the effect of HCAs on glucagon-like peptide-1 (GLP-1).
GLP-1 is a hormone produced by L cells, which is an intestinal endocrine cell that can enhance insulin secretion and lower blood sugar.
HCAs lower blood sugar diagram In a laboratory environment, different types of bile acids (including HCAs) are applied to L cells at different concentration levels.
The results show that, compared with other types of bile acids, high concentrations of 50 micromolar HCAs are the most effective in stimulating GLP-1 secretion.
The research results also show that HCAs regulate blood glucose levels by stimulating the secretion of GLP-1 and thereby regulating the production of insulin.
The potential of HCAs for the prediction and treatment of diabetes "Our research provides evidence of how HCAs regulate blood sugar levels and reveals the mechanism by which
HCAs are achieved at the cellular level.
HCAs can be developed as predictive drugs and new treatments for type 2 diabetes.
"Professor Jia said.
"Because the intestinal flora can regulate the metabolism of HCAs, targeting the intestine instead of the pancreas may be a new strategy for the treatment of diabetes.
We will further study how to regulate the intestinal bacteria to increase the secretion of HCAs in diabetic patients," Jia The professor added.
At present, Professor Jia Wei's team has applied for invention patents and has begun to systematically develop new drug products based on the structure of hyocholic acid to treat metabolic diseases.
Reference materials: [1] https://medicalxpress.
com/news/2021-04-reveals-hyocholic-acids-agents-diabetes.
html [2] 21744-w [3] https://medicalxpress.
com/news/2021-03-gut-microbiome-glucose.
html Note: This article aims to introduce medical research progress and cannot be used as a reference for treatment options.
If you need health guidance, please go to a regular hospital for treatment.
