Nature: The absence of histone H1 destroys the chromatin 3D structure and drives the development of lymphoma 

Linked histone H1 protein binds to the nucleosome to help the formation of chromosome tight structure.
we don't know much about its biological function.
B-E (H1B, H1C, H1D and H1E) encoded with H1 protein; Gene mutations, also known as H1-5, H1-2, H1-3, and H1-4, are highly relapsed in B-cell lymphoma, but the pathogenicity of these mutations to cancer and the mechanisms involved are unknown.
, researchers published a paper in the journal Nature that the H1 allebetic gene associated with lymphoma is a gene-driven mutation in lymphoma.
of H1 function can lead to profound structural remodeling of the genome, characterized by a large-scale and concentrated shift in chromatin from a state of tightening to a state of relaxation.
This deconstruction drives unique changes in the metagenetic state, mainly due to the gain of histogene H3 in Lysine 36 (H3K36me2) and/or the loss of inhibitory H3 triple methylation (H3K27me3) at 27 lysine.
these changes unlock the expression of stem cell genes, which are usually silenced during early development.
In mice, the loss of H1c and H1e (also known as H1f2 and H1f4, respectively) gave the reproductive center B cells more adaptable and self-renewing properties, eventually leading to an increase in the potential for reproduction of invasive lymphoma.
, the study's data suggest that the H1 protein usually needs to seal early-development genes into structurally inconsequencable genomic compartments.
researchers also established H1 as a true tumor suppressor, and showed that mutations in H1 are primarily driven by 3D genome recombination, leading to the reprogramming of metastatics and the suppression of developmental silencing genes.
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