Nature: Tumor cells are better at "grabbing" nutrients than T cells.

If the body's immunea "line of defense" against the invasion of "foreign enemies", then T-cells are the "number one killer".
, however, that this "powerful army" that is so large in the blood of the human body is often unable to play a powerful role in the fight against cancer.
September 2, 2020, nature published online the University of Michigan study "Cancer SLC43A2 Alters T cell methionine metabolism and histonemethylation", which details how tumor cells alter T-cell methionine metabolism and histone methylation through the solute vector SLC43A2, revealing the new mechanisms of tumor immune escape.
study pointed out that methionine has the greatest effect on the vitality and function of T cells, tumor cells in the intake of methionine significantly better than T cells, tumor cells by limiting methionine to reduce methyl supply SAM, and thus damage the CD8 T fine histogene H3K79dylation (H3K79me2) and signal transductivity and transcription activation factor 5 (STAT5) signal, resulting in damage to T cell function.
Further studies have found that the transport protein that destroys tumor cells promotes the functional recovery of T cells, replenishes tumor patients with methionine, and restores T-cell function, because high enough levels of methionine mean that both tumor cells and T-cells can get enough nutrients, and T-cells control the ultimate fate of the tumor.
, researchers are working with drug discovery experts to identify a small molecular inhibitor that targets methionine in tumor cells.
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