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The World Health Organization recommends that children with acute diarrhea take 20 mg of zinc daily for 10 to 14 days.
in previous trials, the dose reduced diarrhea but increased the risk of vomiting.
, researchers randomly assigned 4,500 children between the ages of 6 and 59 months with acute diarrhea in India and Tanzania to 5 mg, 10 mg or 20 mg zinc sulfate for 14 days, according to a recent study published in THEJM, a leading medical journal.
three main outcomes were diarrhea that lasted more than 5 days, the number of stools (assessed in non-poor performance analysis) and vomiting (assessed in the advantage analysis) within 30 minutes of taking zinc.
of children with diarrhoea for more than 5 days was 6.5 per cent in the 20 mg group, 7.7 per cent in the 10 mg group and 7.2 per cent in the 5 mg group.
difference between the 20 mg and 10 mg groups was 1.2 percentage points (the upper limit of the 98.75% confidence interval was 3.3), while the difference between the 20 mg and 5 mg groups was 0.7 percentage points (the upper limit of 98.75% CI was 2.8), both below the non-poor quality boundary of 4 percentage points.
of diarrhea in the 20 mg group was 10.7, 10.9 in the 10 mg group and 10.8 in the 5 mg group.
difference between the 20 mg and 10 mg groups is 0.3 stools (98.75% CI is capped at 1.0) and the difference between 20 mg and 5 mg groups is 0.1 stools (98.75% CI is capped at 0.8), both below the non-shoddy boundary (2 stools).
19.3%, 15.6% and 13.7% of patients in the 20 mg, 10 mg and 5 mg groups had vomiting within 30 minutes of taking the drug.
the risk of the 10 mg group is significantly lower than that of the 20 mg group (the relative risk is 0.81; 97.5% CI is 0.67 to 0.96) and the 5 mg group is lower than the 20 mg group (the relative risk is 0.71; 97.5% CI is 0.59 to 0.86).
30 minutes after the dose, patients in the lower dose group were also less likely to vomit.
, it can be seen that lower doses of zinc in children's diarrhea treatment is not bad, and compared to the standard dose of 20 mg, the incidence of vomiting is less likely.
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