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    Home > Biochemistry News > Microbiology News > New Action on Combating Infection Huada launched the Global Phage Library (GPH) program.

    New Action on Combating Infection Huada launched the Global Phage Library (GPH) program.

    • Last Update: 2020-07-28
    • Source: Internet
    • Author: User
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    Bacteriophage is a kind of virus which takes bacteria as host. It is highly targeted. It only infects specific bacteria and does not attack human cells.it's very sci-fi, like nanorobots, which appeared on earth about 3 billion years ago.although bacteriophages belong to the category of viruses, they have a wide range of application value, and can be used to prevent and control all diseases caused or contributed by bacteria, involving agriculture, forestry, fishery, animal husbandry, medicine and other industries.take the medical industry as an example, bacteriophages can be used to prevent and treat two kinds of human diseases: infectious diseases, such as respiratory tract infection, gastrointestinal tract infection, urinary tract infection, abdominal infection, etc.; and complex chronic diseases, such as facial acne, inflammatory bowel disease (IBD), colorectal cancer, obesity, type II diabetes, cardiovascular disease, etc.compared with antibiotics that can kill bacteria, bacteriophages have the advantages of rich species, strong specificity, minimal side effects and easy genetic transformation.in addition to simple and crude killing of bacteria, the designed and modified phages can also be used to target and precisely regulate the functions of bacteria and flora.the phage family is so large that it is more numerous than all other life on earth (including all bacteria) put together - probably more than 10 ^ 31.however, the reality is that the information of phage genome contained in the public database is extremely scarce. As of May 20, 2020, only 9618 complete phage genomes have been stored in NCBI genome, and most of them lack the corresponding host genome information.the scale of existing phage libraries is also very limited, which generally only contains hundreds of phages or can infect specific types of bacteria, and there is no complete genome or phenotype data, which seriously limits the understanding of phages and the interaction between phages and hosts.bacteriophages are infecting bacteria (photo source: MIT). In order to promote researchers at home and abroad to jointly develop modern research methods of open source, mutual benefit and win-win cooperation, in order to promote the rapid development of phage field beyond the technical barrier, and to facilitate experts and scholars to focus on really important scientific research issues, Shenzhen Huada Institute of life sciences launched the global phage project The global phage hub project is expected to rapidly build the largest phage entity and data integration Library in the world in the form of cooperation and sharing.Global phage hub is the first shared large-scale phage library in China. It is the first time in the world to collect the information of bacteriophages and their host bacteria, and build a library corresponding to the entity, genome and phenotype data, and share it with universities and scientific research institutions, which will effectively promote the development of phage research and application.relying on the world's leading resources and platforms of Huada, this grand scientific program has successfully realized the localization of sequencer and sequencing reagents to prevent being stuck by overseas suppliers. Now it has a series of domestic ultra-high-throughput bgiseq, mgiseq and dnbseq series sequencing systems with completely independent intellectual property rights, and has the ability of super large-scale biological information computing and high-performance analysis, To realize the penetration of data storage and analysis, and provide big data source guarantee for research; based on the self built advanced synthetic biological intelligent construction platform (intelligent) Biofoundry has established phage related genomic extraction, sequencing, analysis, design, synthesis, functional verification, artificial intelligence learning and other processes, realizing the full penetration of the concept of automation, high-throughput, and intelligence, which liberates researchers from a large number of complex labor, and greatly improves the repeatability and efficiency of output.what resources can BGI intelligent biofoundry gain from joining the alliance's member teams? The first phase of the pilot plan is from May 20, 2020 to December 31, 2020. Through cooperation and sharing, Huada will support universities, scientific research institutions, hospitals and other institutions to sequence, assemble and annotate phage and host bacteria genomes.if the team promises to share more than a certain number of phages within two years, Huada will also support the extraction of phage and its host genome.the member teams participating in this program will obtain the right to use the entity, original data and analysis results of phage and its host bacteria voluntarily shared by other member teams of global phase hub after the term agreed in the agreement.the more the number or the rarer the species of phages contributed, the greater the rights and interests of the member team.for example, Huada can match the most suitable phage for a specific host based on the self-developed artificial intelligence algorithm, and accurately verify the ability of phages to cleave specific hosts based on the self-developed high-throughput phenotypic quantitative analysis platform.in the future, the alliance will publish its achievements in the form of albums, special issues or high impact articles, and the list of authors will also be sorted by contribution.can teams without bacteriophage research experience join the alliance? Of course, we hope that more teams from universities, scientific research institutions and hospitals will pay attention to this field, and join the research in this field through college students' course teaching and scientific research projects.as long as the member team has or is able to mine a large number of bacteria resources and can allocate laboratory personnel to carry out relevant research, Huada will provide detailed phage experiment procedure documents and remote technical support.if the team members promise to share more than a certain number of phages within two years, Huada will also provide 1-2 weeks of phage experiment training.according to the cooperation experience of Huada with the hospital in the past, two newly trained postgraduates or technicians can isolate and purify about 200 phages within half a year.as of May 20, 2020, in addition to Huada, the following units have contributed to the global phase hub: Xiangya Hospital of Central South University, Shenzhen Institute of advanced technology, Chinese Academy of Sciences, Dutch phage library (Overseas) Shenzhen Third People's Hospital, Duke University (Overseas), Tsinghua University Medical School, Guangdong Provincial People's Hospital, looking forward to your joining Co sponsor: how to apply to join the alliance? Interested teachers and partners from universities, scientific research institutions and hospitals should send email to bgi-phage@genomics.cn Contact Yin Jiefang for cooperation agreement, sample information sheet and phage experiment steps. We will give feedback within three working days.extensive reading: the phage intelligent mining and analysis tool independently developed by Dr. Xiao Minfeng of Shenzhen Huada Institute of life sciences was published in the world famous academic journals W. song, H. X. sun, C. Zhang,... Y. Shen, J. Li, The novel coronavirus pneumonia is L. You and M. Xiao (2019). Prophage Hunter: an integrative hunting tool hunting, the new M. is the hot spot. It is difficult to stop the spread of the new crown virus. The group immunity is the driving force. 100 thousand people are hot. 20 years of follow-up: 1 glasses of sugar drink every day, the risk of cardiovascular disease is increased by nearly 20%. The three issue of novel coronavirus pneumonia research results published in the top issue of the Journal Moderna published early COVID-19 vaccine data, all patients produced antibodies fever Wen: Nature proteome research reveals new crown pneumonia new therapeutic targets. 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