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    Home > Active Ingredient News > Infection > New Action on Combating Infection Huada Launches Global Phage Library (GPH) Program

    New Action on Combating Infection Huada Launches Global Phage Library (GPH) Program

    • Last Update: 2020-06-24
    • Source: Internet
    • Author: User
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    Phage is a class of bacteria-hosted viruses, highly targeted, only infect specific bacteria, and do not attack human cellsIt's very sci-fi-like, like a nanorobot, and it appeared on Earth about 3 billion years agophage, although it belongs to the virus category, but has a wide range of application value, can be used to prevent and control all diseases caused or contributed by bacteria, involving agriculture, forestry, fishing, animal husbandry, medicine and other industriestaking the medical industry as an example, phage can be used to prevent and treat two major types of human diseases: infectious diseases, such as respiratory infections, gastrointestinal infections, urinary tract infections, celiac infections, etc.; Compared with antibiotics that can also kill bacteria, phage has the advantages of being extremely rich, very specific, having very few side effects and easy genetic modificationIn addition to simply and brutally killing bacteria, designed phages can also be used to target the function of precisely regulating bacteria and floraa large family of phages, and they are more numerous than all the other life on Earth, including all bacteria -- perhaps more than 10 to 31The reality, however, is that the public database contains an extremely poor number of phage genomes, and as of May 20, 2020, NCBI Genome stores only 9618 full genomes of phages, mostly lacking corresponding host genome informationExisting phage physical libraries are also limited in size - typically containing only a few hundred phages that can only infect specific types of bacteria, and there is no well-developed genomic or phenotype data, which severely limits scientists' understanding of the interaction of phages and phages with the hostPhage is infecting bacteria (picture source: MIT)in order to promote researchers at home and abroad to develop open source mutual benefit, win-win modern scientific research methods, but also to promote the rapid development of the phage field across the technical barrier, but also to focus on the really important scientific research issues itself to facilitate, Shenzhen Huada Institute of Life Sciences launched the Global Phage Library (Global Phage Hub) program, looking forward to the form of cooperation and sharing, the world's largest data integrationGlobal Phage Hub is the first shared large-scale phage library in China, the world's first collection of phage and its host bacteria information, and the entity and genome, phenotype data one by one corresponding library, with the vast number of universities and scientific research institutions, will effectively promote the development of phage research and application stakesthe large scientific program relies on China University's world-leading resources and platforms: has successfully realized the localization of sequencers and sequencing reagents to eliminate the neck of overseas suppliers, now has full independent intellectual property rights of the domestic ultra-high-volume BGISEQ, MGISEQ, DNBSEQ series sequencing system, sequencing costs independently controllable; Research provides big data source protection, based on the self-built advanced synthetic bio-intelligence platform (Intelligent BioFoundry) to establish phage-related genome extraction, sequencing, analysis, design, synthesis, functional verification, artificial intelligence learning and other processes, to achieve automation, high throughput, intelligent thinking throughout, the release of researchers from a large number of complex labor, can greatly improve the repeatability and efficiency of outputWhat resources does THE BGI Intelligent BioFoundryto join the alliance's team?the pilot period of the first phase of the plan 2020.5.20-2020.12.31, Huada will be for the vast number of universities, scientific research institutions, hospitals and other units free of charge for the phage and its host bacteria genome sequencing, assembly, annotationIf the member team commits to sharing a certain number of phages within two years, Huada will also free the extraction of the genome of the phage and its host bacteria The team participating in this program will be granted access to the entities, raw data, and results of the analysis of phages and their host bacteria voluntarily shared by other members of the Global Phage Hub team after the agreed period The more or less the type of contributor y8, the greater the benefit that the team of members will gain For example, Huada can accurately verify the ability of phage to crack a specific host based on self-developed artificial intelligence algorithms for a specific host, and a high-throughput phenotytype quantitative analysis platform based on self-developed high-throughput phenotypes The Alliance will partner in future publications in the form of albums, special issues, or high-impact articles, and the list of authors will be sorted by contribution can teams with no phage research experience to join the alliance? of course, I hope that more teams from universities, scientific research institutions, hospitals pay attention to the field, as well as through the teaching of college students, scientific research projects and other forms to join the field of research As long as the member team has or can tap a large number of bacterial resources and can assign experimenters to engage in relevant research, Huada will provide detailed phage experimental steps documentation and remote technical support If the member team commits to sharing more than a certain number of phages within two years, Huada will also provide 1-2 weeks of phage experimental training According to Huada's previous experience with the hospital, two newly trained master's students or technicians can be isolated and purified within six months to obtain about 200 phages As of May 20, 2020, the following units have contributed to Global Phage Hub in addition to Huada: Xiangya Hospital of Central South University
    the Shenzhen Advanced Technology Research Institute of the Chinese Academy of Sciences the Netherlands Phage Library (Overseas) the Third People's Hospital of Shenzhen The of the Of Co-sponsors: How do apply to join the alliance? please send an email to teachers and partners from universities, research institutions and hospitals to bgi-phage@genomics.cn to ask for cooperation agreements, sample information sheets, phage experimental steps, we will give feedback within three working days Source: of Biological Exploration
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