New advances in the study of redox balance and new diagnostic and therapeutic strategies—the development of sentinel markers of exercise and antioxidant interventions to effectively regulate diabetes and healthy homeostasis

The occurrence and development of major diseases (including tumor, cardiovascular, metabolic diseases) is the main factor leading to patient death, with the theoretical development of modern medicine and scientific and technological progress, people have found the importance of redox (REDOX) balance in maintaining human health and homeostasis

Figure 1: Professor Liu Shanlin of Fudan University, chairman of the Oxygen Balance Strategy Seminar, made a keynote speech at the offline venue, and Academician Qian Xuhong of East China Normal University presided over it

Diabetes is representative of chronic metabolic diseases, its occurrence is closely related to obesity and health levels, and has become a global public health problem

Recently, experts from Fudan University and East China Normal University in the field of free radical medicine jointly published a biomarker in the internationally renowned journal eLife entitled "Hepatic AMPK signaling activation in response to dynamic REDOX balance is a biomarker of.

Moderate exercise can alleviate symptoms of many disorders, including mental, neurological, metabolic, cardiovascular, pulmonary, musculoskeletal, and even cancer(1

Figure 2: AMPK can be used as an outpost biomarker for exercise and antioxidant therapy for diabetes

(Source: Wu ML.

The discovery of oxygen equilibrium outpost markers in this study can help scientifically define the state of oxygen equilibrium; The authors use bell curves to describe the relationship between ROS and physiological function under exercise and antioxidant interventions, and also convincingly suggest that exercise and antioxidant interventions need to be individualized

Professor Liu Shanlin, a senior expert in the field of free radical medicine in China, and Professor Shi Dongyun of Shanghai Medical College of Fudan University are the co-corresponding authors of this paper, and the specific experimental work is jointly completed

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