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| The new method can reduce the side effects of antibiotic treatment, and the combination of erythromycin and antidote can protect beneficial intestinal bacteria |
Recently, an international research team led by German scientists analyzed the effects of 144 antibiotics on common human intestinal bacteria and proposed a new method to reduce the negative impact of antibiotic treatment on the intestinal microbiota
.
Related results were published in the recent "Nature" magazine
Recently, an international research team led by German scientists analyzed the effects of 144 antibiotics on common human intestinal bacteria and proposed a new method to reduce the negative impact of antibiotic treatment on the intestinal microbiota
Dr.
Lisa Mayer of the "Controlling Microorganisms Against Infections" Excellence Cluster (CMFI) at the University of Tubingen explained: "Many antibiotics inhibit the growth of pathogenic bacteria
.
This broad activity can be used to treat infections, but it increases the intestinal Beneficial bacteria are also at risk of attack
Based on the research team's early research, the team studied how each of 144 antibiotics affects the growth and survival of 27 common bacteria in the intestine
.
They determined the effect of specific antibiotics on the concentration of bacterial strains, involving more than 800 combinations of antibiotics and strains
The research team further proposed ways to reduce the negative impact of antibiotics on the gut microbiota
.
Tipas said: "In previous studies, we were able to prove that the drug combination has different effects on different types of bacteria
Researchers combined antibiotics such as erythromycin or doxycycline with nearly 1,200 drugs, and finally discovered several non-antibiotic drugs that can protect these gut bacteria
.
Subsequent experiments show that this method is also applicable to the natural microbiome
Maier said: "There is no single antidote that can protect all the bacteria in our intestines, mainly because they vary from person to person
.
But this concept opens the door to the development of new personalized strategies to protect gut bacteria
