New research has found clues to the evolution of the new coronavirus, or vaccine design.

This article is reprinted from "China News Network". A novel coronavirus research paper published in's natural academic journal, natural structure and molecular biology, said that the structure of new spike coronavirus (SARS-CoV-2) and its associated bat RaTG13 virus (PRP) can be combined with cells and enter cells. The process provides information, which may be useful for vaccine design.according to the paper, the researchers believe that bat coronavirus may be the evolutionary precursor of NCV, and previous studies have found that the genetic relationship between bat virus ratg13 and NCV is the closest among the known relationships.however, it is not clear how the new coronavirus evolved to infect humans, and whether it was transmitted directly to humans through an intermediate host.Antoni Wrobel, Donald Benton and their colleagues, who are experts in virology at Francis Crick Institute in London, UK, and their colleagues, compared the spike glycoproteins of NCV and ratg13, and found that although they are similar in structure, the form of NCV spike glycoprotein is more stable and has affinity with human receptor protein ACE2 About 1000 times higher.they also found that the Flynn cleavage site on the spike of the new coronavirus may be beneficial to the virus, as it may promote the binding of the virus to cellular receptors.based on these observations, the authors believe that bat viruses similar to ratg13 are unlikely to infect human cells, which also supports the theory that the new coronavirus evolved after recombination of different coronavirus genomes.the authors pointed out that the new coronavirus spike glycoprotein they studied had high resolution, nearly complete structure and more external loops than previously reported, which may be of great significance for vaccine development and design.end in the past selected to watch nature: "naked mole rats riding the wind and waves" are not afraid of cancer because of this "super ability"? Hot Science: Global AIDS cure or now the third person, 66 weeks after drug withdrawal, HIV was not detected. Xie Ying, new general manager of CST: after the new crown epidemic, many disease mechanism research will be accelerated. Hot article JAMA sub: easy to dream rapid eye movement sleep reduction, death risk will increase, hot Wen pressure, poor ability! Cell reveals the stress mechanism of brown adipocytes: Medical immunotherapy | bionic drugs | vaccine | drug resistance | drug target | healthy life | pharmaceutical enterprise news | drug inventory | pharmaceutical technology | basic research on drug side effects / translational medicine leukemia | lung cancer | gastric cancer | colorectal cancer | liver cancer | breast cancer | pancreatic cancer | cardiovascular disease | God Through degenerative diseases | intestinal microbiological medical devices / Biotechnology in vitro diagnosis | medical devices | biological nano | 3D printing | gene detection | single cell sequencing | gene editing | assisted reproduction | artificial intelligence | precision medicine policy | anticancer drugs | 4 + 7 bulk purchase | consumables | filing system | registrant system | healthy China | NEW basic drug catalog |AI medical devices | telemedicine | same share different rights market / capital IPO | financing | cooperation | fund | Hong Kong Stock Exchange | science and technology innovation board | growth enterprise market | R & D investment | acquisition | Market & amp; consumption