New theory may completely change the treatment of endometriosis

NEJM

NEJM

Endometriosis (endometriosis) refers to a common painful gynecological disease in women formed when active endometrial cells are planted outside the endometrium.

Endometriosis (endometriosis) refers to a common painful gynecological disease in women formed when active endometrial cells are planted outside the endometrium.

Testosterone Testosterone plays a key role in its development.

Endometriosis is caused by the growth of endometrial tissue outside the uterus, usually in the pelvic region, which can cause pain, inflammation and infertility.

The new study is based on recent findings that women with endometriosis develop fetuses in their mother's womb under relatively low testosterone conditions compared to women without endometriosis .

Compared with women without endometriosis, women with endometriosis have a relatively low fetus in their mother’s womb compared with women without endometriosis.

(1) Highly aggressive placenta formation;

(1) Highly invasive placenta formation; (1) Highly invasive placenta formation;

(2) Endometrial decidualization that is spontaneous and not driven by implantation;

(2) Endometrial decidualization that is spontaneous and not driven by implantation ; (2) Endometrial decidualization that is spontaneous but not driven by implantation;

(3) Frequent and extensive estrogen-driven endometrial hyperplasia and inflammation, followed by massive menstrual bleeding.

(3) Frequent and extensive estrogen-driven endometrial hyperplasia and inflammation, followed by massive menstrual bleeding.

Tinbergen's summary of four questions on understanding the evolutionary risks, development, adaptive significance and mechanisms of endometriosis and its related phenotypes.

Tinbergen's summary of four questions on understanding the evolutionary risks, development, adaptive significance and mechanisms of endometriosis and its related phenotypes.

The hypotheses described and evaluated here have led to many testable predictions and have direct implications for the treatment and research of endometriosis.

The researchers found that their theory is supported by a series of significant data in the literature, ranging from genetics and development to endocrinology, morphology, life history, and evolutionary biology, thereby providing features related to endometriosis The first comprehensive explanation.

Bernard Crespi, Chair of Canadian Research and Professor of Biological Sciences at SFU, said: "Low testosterone in early development is the strongest known factor associated with endometriosis, and its influence can explain most of the symptoms of endometriosis.

Crespi pointed out that in the study of endometriosis, testosterone was clearly ignored because it is generally considered a "male" hormone, although it is known to have a key effect on women.

Ben Trumble, an assistant professor at Arizona State University's School of Human Evolution and Social Change, praised the author for surpassing the blind spots of binary hormones.

The author transcends the blind spots of binary hormones and transcends the blind spots of binary hormones

The model of how prenatal testosterone mediates the risk of endometriosis and PCOS is determined by the influence of the main hormones that regulate the HPO axis in women.

The model of how prenatal testosterone mediates the risk of endometriosis and PCOS is determined by the influence of the main hormones that regulate the HPO axis in women.

These models show how the effects of increased and decreased prenatal testosterone levels on HPO axis development in women mediate the risk of PCOS and endometriosis, and how these effects produce the symptoms of each disease.

These models show how the effects of increased and decreased prenatal testosterone levels on HPO axis development in women mediate the risk of PCOS and endometriosis, and how these effects produce the symptoms of each disease.

This work established endometriosis as a developmental endocrine disease that originated in the early stages of life.
It also clarifies the relationship between endometriosis and polycystic ovary syndrome, which is caused by high prenatal testosterone levels rather than low levels.
The study showed that polycystic ovary syndrome is basically the opposite of endometriosis in its etiology, related factors and main symptoms.
Therefore, this work should help change our understanding of these two diseases.

Original source:

oup.
com/emph/article/9/1/174/6168997" target="_blank" rel="noopener">The evolutionary biology of endometriosis .
DOI:https://doi.
org/10.
1093/emph/eoab008

oup.
com/emph/article/9/1/174/6168997" target="_blank" rel="noopener">The evolutionary biology of endometriosis

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