NMN: Star API on the road to "Seal god"

Yuntian NMN as a new star raw material, its full name niacinamide mononucleotide, is the reaction product of niacin phosphate RNA transferase, mainly in the body as a key preludes of NAD plus, through transformation to play physiological functions, such as activation of NAD-base dependent enzyme Sirt1 (histone deacetylase), regulation of cell survival, death and maintenance of redox state.
confirmed that NMN levels are associated with cardiovascular disease, neurodegenerative diseases, diabetes and obesity.
diagram I NMN structure from the medicinal effects, NMN has now proved that the functions include: 1. Relieve and improve ischemic heart and brain tissue damage a. Stroke treatment.
stroke is an acute cerebrovascular disease caused by blood circulation disorders in the brain, characterized by high mortality and disability rates.
study found that NMN activates the Nampt-NAD-plus pathway, protects the nerves of the brain, and promotes blood vessel and nerve regeneration, which has a good protective effect on nerve damage caused by cerebral hemorrhage and brain haemorrhage transformation, and is therefore a potential anti-stroke drug.
b. Heart isoemia re-perfusion therapeutic effect.
ischemia refilling is a fatal ischemia injury associated with unavoidable cardiac cell death and severe organ dysfunction.
isoemia pre-treatment (IPC) is an endo-defensive mechanism that protects the vitality of the heart muscle during transient isoemia refurbation by activating Sirt1-mediated defense mechanisms.
studies have shown that NMN protects the heart by simulating the protective effects of isoemia pre-treatment (IPC).
2. Improving the treatment of oxidative-related detocative diseases and body dysfunctiona. Alzheimer's disease.
study found that abnormal mitochondrial structure and function are one of the pathogenic factors of Alzheimer's disease, and NMN promotes the energy metabolism of mitochondrials, which plays an important role in improving cognitive function and memory function.
b. Treatment of Parkinson's disease.
studies have shown that NMN can improve nerve cell survival, stabilize NAD-plus and ATP levels, inhibit apoptosis, resist energy damage, and improve mitochondrial inhibitors to induce energy metabolism disorders, thereby benefiting the treatment of Parkinson's disease.
c. The therapeutic effect of vascular disorders.
studies have shown that NMN reduces vascular oxidative stress, improves aortic hardening and vascular dysfunction, and that NMN reduces collagen accumulation in blood vessels, while increasing the accumulation of arterial elastin and reducing atherosclerosis in the body, thereby delaying pulse aging.
, NMN has been shown to have the effect of treating acute kidney injury, delaying aging, treating vision deatocation diseases, etc.
3. The treatment of metabolic diseases NMN is mainly used for the improvement of diabetes and obesity in metabolic diseases.
studies have found that NMN can improve islet function in high fructose mice by participating in glucose metabolism, anti-inflammatory, and apoptosis processes;
, NMN is also getting more and more attention, and its demand for API is increasing.
, the author here for you to show two synthetic technology for your reference.
diagram II NMN synthesis process one of them is Mukhailopulo et al. developed to triamyl-β-D-ucose (2) as the starting material, by bromide generation, niacinamide replacement, debenhamyl protection base, phosphate to produce the target product NMN.
the method has a shorter step and a higher total yield.
but there are environmentally unfriendly, more expensive raw materials and other issues.
three NMN synthesis process two and the second is based on the process one of the improved process.
the process to acetyl nuclear sugar as raw material, the same by brominated generation, niacinamide replacement, debenhamyl protection base, phosphate to produce the target product NMN.
, the process has the characteristics of cheap and easy-to-use raw materials, milder reaction conditions and high atomic economy.
in all, researchers have not stopped developing better NMN processes, and at the same time, as NMN research continues to deepen, its medicinal needs will continue to grow.
second, NMN's health care functions in areas such as anti-aging and improved obesity have been recognized, and the demand for re-health foods is expected to grow significantly, as well as a drug of concern and potential health food.
References: 1. Progress on research and application of nicotinamide mononucleotides, 2018; 2. Progress in Synthsis of β-Nicotinamide Mononucleotide,2020; 3. Advance in Synthesis of β-Nicotinamide Mononucleotide,2020.