NMN: Star API on the road to "Seal god"

NMN as a new star raw material, its full name niacinamide mononucleotide, is the reaction product of niacinamide phosphate RNA transferase, mainly as a key prelub of NAD plus in the body, through transformation to play physiological functions, such as activation of NAD-substrate dependent enzyme Sirt1 (histone deacetylase), regulation of cell survival, death and maintenance of oxidation reduction state. Studies have confirmed that NMN levels are associated with cardiovascular disease, neurodegenerative diseases, diabetes and obesity.In terms of medicinal effects, NMN has now proven functions include: 1. Relieving and improving ischemic heart and brain tissue damage a. Stroke therapy. Stroke is an acute cerebrovascular disease caused by blood circulation disorders in the brain, characterized by high mortality and disability rate. The study found that NMN activates the Nampt-NAD plus pathway, protects the nerves of the brain, and promotes blood vessel and nerve regeneration, which has a good protective effect on nerve damage caused by brain haemorrhage and cerebral hemorrhage transformation, and is therefore a potential anti-stroke drug.b. Heart isoemia re-perfusion therapeutic effect. Heart ischemia refill is a fatal ischemia injury, which is accompanied by unavoidable cardiac cell death and severe organ dysfunction. Isoemia Pre-Treatment (IPC) is an endopathic defense mechanism that protects the heart muscle vitality during transient isoemia refill by activating Sirt1-mediated. Studies have shown that NMN protects the heart by simulating ishemoth pre-treatment (IPC).2. Improving oxidation-related detocative diseases andthe therapeutic effects of Alzheimer's disease. It is found that abnormal mitochondrial structure and function are one of the pathogenic factors of Alzheimer's disease, and NMN promotes the energy metabolism of mitochondrials, which plays an important role in improving cognitive function and memory function.b. The therapeutic effect of Parkinson's disease. Studies have shown that NMN can improve nerve cell survival, stabilize NAD-plus and ATP levels, inhibit apoptosis, resist energy damage, and improve mitochondrial inhibitors to induce energy metabolism disorders, thereby benefiting the treatment of Parkinson's disease.c. The therapeutic effect of vascular disorders. The study confirmed that NMN can reduce vascular oxidative stress response, improve aortic sclerosis and vascular dysfunction, in addition, NMN can reduce collagen accumulation in blood vessels, and increase the accumulation of arterial elastin, reduce the body's arteriosclerosis, thereby delaying pulse aging.d. In addition, NMN has been shown to have the effect of treating acute kidney injury, delaying aging, treating vision deatocation diseases, etc.3. Treatment of metabolic diseasesNMN is mainly used for the improvement of diabetes and obesity in metabolic diseases. The study found that NMN can improve the islet function of high fructose mice by participating in glucose metabolism, anti-inflammatory and apoptosis processes, in addition, NMN can restore insulin secretion by catalyticizing the biosynthesis of mammalian NAD-plus, and the increase in NAD-plus levels can enhance mitochondrial energy metabolism, which in turn can achieve weight loss similar to exercise.In China, NMN is also getting more and more attention, and its demand for RAW drugs is increasing. Therefore, the author here for you to show two synthetic technology for your reference.One is that Mukhailopulo et al. developed a target product NMN based on triammolyl-β-D-ucose (2), which is replaced by bromide, niacinamide, debenhamyl protection, and phosphate. The method has short steps and a high total yield. However, there are problems such as unfriendly environment and more expensive raw materials.The second is an improved process based on process one. The process is based on acetylucleose, which is also the target product NMN produced by bromide, niacinamide replacement, debenhamyl protection base and phosphate. Compared with route one, the process has the characteristics of cheap and easy-to-use raw materials, milder reaction conditions and high atomic economy.All in all, researchers have not stopped developing better processes for NMN, and at the same time, as NMN research continues to deepen, its medicinal needs will continue to grow. Secondly, NMN's health care functions in the areas of anti-aging and improved obesity have been recognized, and the demand for re-health food is expected to grow significantly, which is a drug of concern and potential health food. (CPhI Pharmaceuticals Online):1. Progress on research and application of nicotinamide mononucleotides, 2018;2. Progress in Synthsis of β-Nicotinamide Mononucleotide,2020; 3. Advance in Synthesis of β-Nicotinamide Mononucleotide,2020.