One article review: What are the drugs that may increase liver enzyme levels?

A variety of drugs can cause abnormal levels of liver enzymes in some individuals, including: pain relievers, antiepileptic drugs, antibiotics, cholesterol-lowering drugs, cardiovascular drugs,
etc.

It is sorted as follows: Drugs with potential hepatotoxicity 1.
Painkillers: aspirin; acetaminophen (Tylenol, etc.
); ibuprofen (Advil, ibuprofen); naproxen (naproxen, naproxen Diclofenac sodium (Voltaren, Voltaren sustained-release tablets); Phenybutazone
.

2.
Antiepileptic drugs: phenytoin (phenytoin sodium); valproic acid (divalproex sodium); carbamazepine (carbamazepine tablets); phenobarbital
.

3.
Antibiotics: tetracycline antibiotics (eg, tetracycline); sulfonamides; isoniazid (INH); sulfamethoxazole; trimethoprim; nitrofurantoin (nitrofurantoin; nitrofurantoin capsules); fluconazole and some other antifungals drugs,
etc.

4.
Cholesterol-lowering drugs: lovastatin; pravastatin; atorvastatin; fluvastatin; simvastatin; rosuvastatin; niacin
.

 5.
Cardiovascular drugs: amiodarone; hydralazine; quinidine,
etc.

 6.
Other drugs: tricyclic antidepressants
.

Drug-induced liver enzyme abnormalities that usually resolve within weeks or months of stopping the drug
.

Typically, a doctor will want to monitor changes in a patient's liver enzymes over time to see if liver enzyme levels are normalizing
.

Conditions leading to very high AST and ALT levels Certain disease conditions that lead to the rapid death of large numbers of liver cells (extensive hepatic necrosis) tend to have very high AST and ALT levels
.

Although this degree of elevation of liver enzymes is uncommon, it can be seen in: • acute hepatitis A or B • severe liver damage from toxins such as excess acetaminophen or mushroom poisoning • supply in the liver Long-term breakdown of the circulatory system (shock) when the blood flow for oxygen and nutrients is reduced.
Also, very high AST and ALT levels can occur with severe muscle disease
.

Uncommon causes of elevated liver enzymes • Hemochromatosis is a genetic disorder where a diet high in iron causes iron to accumulate in the liver, leading to inflammation and scarring of the liver
.

If undiagnosed or untreated, hemochromatosis can progress to cirrhosis and liver failure
.

• Wilson's disease is an inherited disorder in which copper accumulates excessively in various tissues including the liver and brain
.

Too much copper in the liver can lead to chronic liver inflammation, while copper in the brain can cause psychosis and movement disorders
.

• Alpha-1-antitrypsin deficiency is an inherited disorder in which the glycoprotein called alpha-1-antitrypsin is deficient, causing chronic lung disease (emphysema) and chronic liver disease
.

• Celiac disease is a disease of the small intestine
.

Mildly abnormal ALT and AST levels can also occur in patients with celiac disease
.

• Crohn's disease and ulcerative colitis are chronic inflammatory diseases of the bowel (collectively known as inflammatory bowel disease)
.

In these individuals, inflammation of the liver (hepatitis) or cholangitis (primary sclerosing cholangitis) may also occur, causing abnormal liver tests
.

Yimaitong compiled from: Liver Blood Tests:Understand Liver Blood Test Results.
MedicineNet.