One of the top ten most effective antioxidant vegetables!

Insulin resistance (IR) is a pathological state in which the body's cells do not adequately respond to insulin hormones

Insulin resistance (IR) is a pathological state in which the body's cells do not adequately respond to insulin hormones

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Beetroot contains a variety of minerals, including potassium, sodium, phosphorus, calcium, magnesium, copper, iron, zinc, and manganese, as well as bioactive compounds such as betalains, saponins, polyphenols, and flavonoids

Sixteen male Wistar rats (32 weeks old) were divided into two equal groups: control and RBJ

Sixteen male Wistar rats (32 weeks old) were divided into two equal groups: control and RBJ

No deaths occurred during the study period

At the start of the study, the mean ± SD of body weight in the control and RBJ groups was 356.

At the start of the study, the mean ± SD of body weight in the control and RBJ groups was 356.

The SBP results showed that there were no significant differences between the study groups

Compared with normal control rats, RBJ intake significantly increased AST levels (p<0.

The fasting plasma glucose (FPG) level in the control group was significantly higher than that in the RBJ ( P< 0.

The HOMA-IR index (HOMA-IR > 2.

The HOMA-IR index (HOMA-IR > 2.

As shown in Figure 1b, the basal insulin levels of the control animals were significantly higher than those of the RBJ group

As a result, the AUC of plasma insulin concentration in the RBJ group was significantly lower than that in the control group (p < 0.
001)
.

As a result, the AUC of plasma insulin concentration in the RBJ group was significantly lower than that in the control group (p < 0.
001)
.

Effects on pancreatic insulin secretion

Effects on pancreatic insulin secretion

The results showed that at supraphysiological (16.
7 mM/L) glucose concentrations, the pancreatic insulin secretion in the RBJ group was lower than that in the control group (p<0.
05) (Fig.
2)
.

The results showed that at supraphysiological (16.
7 mM/L) glucose concentrations, the pancreatic insulin secretion in the RBJ group was lower than that in the control group (p<0.
05) (Fig.
2)
.

To investigate the role of NO in inhibiting pancreatic insulin secretion from RBJ islets, NOS inhibitors (AG) were used
.
It was found that AG reduced insulin secretion in the control islets at both postprandial glucose concentrations (8.
3 mM/L) and supraphysiological concentrations (16.
7 mM/L) (p < 0.
001 )
.
After incubation of RBJ islet cells with AG, insulin release decreased only at supraphysiological concentrations (16.
7 mM/L) (p < 0.
05 , Figure 2)
.

To investigate the role of NO in inhibiting pancreatic insulin secretion from RBJ islets, NOS inhibitors (AG) were used
.
It was found that AG reduced insulin secretion in the control islets at both postprandial glucose concentrations (8.
3 mM/L) and supraphysiological concentrations (16.
7 mM/L) (p < 0.
001 )
.
RBJ decreased at supraphysiological concentrations (16.
7 mM/L) (p < 0.
05 , Figure 2)
.

Endogenous nitric oxide inhibition had a greater effect on insulin release in the control group than in the RBJ group [49.
91%±6.
4% vs 31.
16%±2.
8% at 8.
3 mM/L (p < 0.
05 ), 64.
40%±2.
9% at 16.
7 mM/L] than 50.
51% ± 5.
2% (p < 0.
05 )]
.

Endogenous nitric oxide inhibition had a greater effect on insulin release in the control group than in the RBJ group [49.
91%±6.
4% vs 31.
16%±2.
8% at 8.
3 mM/L (p < 0.
05 ), 64.
40%±2.
9% at 16.
7 mM/L] than 50.
51% ± 5.
2% (p < 0.
05 )]
.

Effects on NOx and MDA

Effects on NOx and MDA Effects on NOx and MDA Effects on NOx and MDA

Serum NOx levels were significantly increased in the RBJ group compared with the control group (p < 0.
01, Figure 3e)
.
In addition, the NOx contents in the aorta, heart, and especially liver tissue of the RBJ - treated rats were all statistically higher than those of the control group (p < 0.
05, Fig.
3f–h) .

Serum NOx levels were significantly increased in the RBJ group compared with the control group (p < 0.
01, Figure 3e)
.
In addition, the NOx contents in the aorta, heart, and especially liver tissue of the RBJ - treated rats were all statistically higher than those of the control group (p < 0.
05, Fig.
3f–h) .

Serum, cardiac and aortic MDA levels were unchanged in the RBJ group compared with the control group (Fig.
3a–c)
.
However, the level of hepatic lipid peroxidation in the RBJ group was significantly higher than that in the control group (p < 0.
01, Fig.
3d)
.
However, to the best of our knowledge, its effect on islet function has not been investigated
.
Therefore, this study aimed to investigate the effect of red beetroot juice (RBJ) consumption on carbohydrate metabolism in adult insulin-resistant rats, focusing on islet insulin secretion and oxidative status
.

Serum, cardiac and aortic MDA levels were unchanged in the RBJ group compared with the control group (Fig.
3a–c)
.
However, the level of hepatic lipid peroxidation in the RBJ group was significantly higher than that in the control group (p < 0.
01, Fig.
3d)
.
However, to the best of our knowledge, its effect on islet function has not been investigated
.
Therefore, this study aimed to investigate the effect of red beetroot juice (RBJ) consumption on carbohydrate metabolism in adult insulin-resistant rats, focusing on islet insulin secretion and oxidative status
.
However , to the best of our knowledge, its effect on islet function has not been investigated
.
Therefore, this study aimed to investigate the effect of red beetroot juice (RBJ) consumption on carbohydrate metabolism in adult insulin-resistant rats, focusing on islet insulin secretion and oxidative status
.

In conclusion, RBJ-treated rats exhibited lower blood glucose and insulin levels in glucose tolerance tests compared with controls
.
Serum and tissue nitric oxide levels in the RBJ group were significantly higher than those in the control group
.
Liver peroxidation and serum aspartate aminotransferase levels were significantly increased in RBJ-treated animals compared with controls
.
Islets in the RBJ group exhibited lower insulin secretion, especially at a glucose concentration of 16.
7 mM (supraphysiological conditions) than in the control group
.

In conclusion, RBJ-treated rats exhibited lower blood glucose and insulin levels in glucose tolerance tests compared with controls
.
Serum and tissue nitric oxide levels in the RBJ group were significantly higher than those in the control group
.
Liver peroxidation and serum aspartate aminotransferase levels were significantly increased in RBJ-treated animals compared with controls
.
Islets in the RBJ group exhibited lower insulin secretion, especially at a glucose concentration of 16.
7 mM (supraphysiological conditions) than in the control group
.

In conclusion, RBJ intake improves glucose metabolism in aged rats by increasing nitric oxide metabolism in an insulin-independent manner
.
However, future studies are needed to minimize potential adverse hepatic consequences
.

In conclusion, RBJ intake improves glucose metabolism in aged rats by increasing nitric oxide metabolism in an insulin-independent manner
.
However, future studies are needed to minimize potential adverse hepatic consequences
.

 

Original source:

Original source:

Sayyar A, Oladi M, Hosseini M, Nakhaee S, Ataie Z, Farrokhfall K.
Effect of red beetroot juice on oxidative status and islet insulin release in adult male rats.
  Diabetol Metab Syndr .
2022;14:58.
Published 2022 Apr 23.
doi: 10.
1186/s13098-022-00830-z

Sayyar A, Oladi M, Hosseini M, Nakhaee S, Ataie Z, Farrokhfall K.
Effect of red beetroot juice on oxidative status and islet insulin release in adult male rats.
  Diabetol Metab Syndr .
2022;14:58.
Published 2022 Apr 23.
doi:10.
1186/s13098-022-00830-z Diabetol Metab Syndr

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