Overview of clinical projects of cancer cell immunotherapy: over 2000 pipelines CAR-...

Cellular immunotherapy for cancer is a therapy in which normal or bioengineered human cells are transplanted or transferred into the body of cancer patients to achieve the effect of cancer treatment

Recently, IQVIA, a world-renowned medical industry consulting company, and the non-profit organization Cancer Research Institute (CRI) published an analyst report titled The clinical pipeline for cancer cell therapies in Nature Reviews Drug Discovery, a subsidiary of Nature, describing It shows the current global clinical research and development picture of cancer cell immunotherapy

CAR-T therapy is still the mainstream, and the application of allogeneic cells is growing rapidly

The main types of cellular immunotherapy include CAR-T, TCR-transduced T cells (TCR-T), tumor infiltrating lymphocytes (TIL) and natural killer (NK) cells, etc.

Picture from Frost & Sullivan analysis

From this report, the global cell therapy pipeline is steadily advancing.

Comparison of cell therapies at different clinical stages from 2019 to 2021

Among more than 2,000 cell therapies, CAR-T is still the mainstream, with 299 new clinical pipelines, an increase of 35% over 2020, and most (80%) pipelines are in preclinical or clinical phase 1

Changes in the pipeline of cellular immunotherapy from 2019 to 2021

CD19, BCMA, etc.

Judging from the five products approved by the FDA, CD19 with four listed drugs and BCMA with one listed product are undoubtedly one of the hottest tracks

Popular targets in the field of hematoma

From the perspective of solid tumors, the research target remains basically unchanged, and the number of undisclosed tumor-associated antigens (TAA) still tops the list

Popular targets for solid tumors

China and the United States are leading the world in research projects, solid tumors are still difficult to treat

The report pointed out that according to the data of ClinicalTrials.

At present, the United States is still the leader in cellular immunotherapy, with 791 cell therapy projects in progress, and China’s domestic enthusiasm for cellular immunotherapy is not inferior, with the number of projects reaching 695.

Global overview of cell therapy drugs by sponsor (academic institutions and pharmaceutical manufacturers)

Cancer is currently one of the hottest tracks for venture capital in the medical and health field, and cellular immunotherapy is considered one of the most promising innovative therapies to overcome tumors

Reference materials:

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