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News from March 11, 2021 //---A study led by researchers from UT Southwest and Child Health defined the number of white blood cells that must be present in children's urine at different concentrations to reveal the urinary tract infection (UTI) risk.
This discovery was recently published in the journal Pediatrics and can help speed up the treatment of this common disease and prevent potential lifelong complications.
This discovery was recently published in the journal Pediatrics and can help speed up the treatment of this common disease and prevent potential lifelong complications.
Among children under 24 months of age, UTI accounts for 7% of fevers and is a common factor in hospital emergency room visits.
However, the study leader, UTSW Assistant Professor of Pediatrics, emergency physician and pediatric nephrologist at Dallas Children’s Medical Center, Dr.
Shahid Nadeem, said that because symptoms are similar to other fever-causing conditions, accurate diagnosis is often difficult.
However, the study leader, UTSW Assistant Professor of Pediatrics, emergency physician and pediatric nephrologist at Dallas Children’s Medical Center, Dr.
Shahid Nadeem, said that because symptoms are similar to other fever-causing conditions, accurate diagnosis is often difficult.
(Image source: Www.
pixabay.
com)
pixabay.
com)
He explained that if the diagnosis is delayed, UTI may develop into a serious infection, which may have lasting consequences.
For example, kidney scarring associated with urinary tract infections is associated with hypertension and chronic kidney disease later in life.
For example, kidney scarring associated with urinary tract infections is associated with hypertension and chronic kidney disease later in life.
In order to diagnose a urinary tract infection, the doctor must culture a urine sample and wait for it to grow bacteria in a petri dish containing nutrients.
However, Nadeem said this process can take up to two days, delaying treatment.
Therefore, he and other doctors usually rely on testing for white blood cell-related proteins (called leukocyte esterase (LE)) in urine, and then identify them by looking for white blood cells (a marker of immune activity) in the urine.
The presence.
However, Nadeem said this process can take up to two days, delaying treatment.
Therefore, he and other doctors usually rely on testing for white blood cell-related proteins (called leukocyte esterase (LE)) in urine, and then identify them by looking for white blood cells (a marker of immune activity) in the urine.
The presence.
He added that in children, the number of white blood cells may be highly variable, and some of these changes may be caused by changes in urine concentration.
Therefore, it is not known which white blood cell count threshold should be used based on urine concentration to start treatment of potential UTI.
Therefore, it is not known which white blood cell count threshold should be used based on urine concentration to start treatment of potential UTI.
To determine these parameters, Nadeem and his colleagues searched the medical records of children under 24 months of age who were taken to the emergency room of the Children’s Medical Center between January 2012 and December 2017, suspected of having UTI, and Urine analysis was performed-in which the urine was evaluated for the concentration of LE and the presence of LE and white blood cells-and urine culture was performed.
The search found 24,171 patients, of which 2,003 were diagnosed with UTI based on urine culture.
The search found 24,171 patients, of which 2,003 were diagnosed with UTI based on urine culture.
Using the specific gravity of their urine (the density of the urine relative to water, as a proxy for concentration) and the number of white blood cells present in the field of high-power microscopy, the researchers came up with the critical point of urine.
Three urine concentration groups: For low urine concentration, children only need 3 white blood cells to suspect urinary tract infection; for medium concentration, the number is 6; for high concentration, it is 8.
Three urine concentration groups: For low urine concentration, children only need 3 white blood cells to suspect urinary tract infection; for medium concentration, the number is 6; for high concentration, it is 8.
Nadeem said that for each concentration group, the white blood cell esterase remained constant-suggesting that this is a good trigger for analyzing the presence of white blood cells in the urine.
He added that understanding how many white blood cells are often present in the urine of different concentrations of urine in children with urinary tract infections can help doctors start treating these infections before they become infected.
This can reduce the burden on patients and their parents and prevent complications.
disease.
Nadeem said: "The sooner we start treatment, the better for these young patients.
" "Our results add more information to the physician's toolbox to make this decision.
" (Bioon.
com)
This can reduce the burden on patients and their parents and prevent complications.
disease.
Nadeem said: "The sooner we start treatment, the better for these young patients.
" "Our results add more information to the physician's toolbox to make this decision.
" (Bioon.
com)
Information source: com/news/2021-03-treatment-urinary-tract-infections-children.
html">Speeding treatment for urinary tract infections in children
html">Speeding treatment for urinary tract infections in children
Original source: Shahid Nadeem et al.
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
(Image source: Www.
pixabay.
com)
pixabay.
com)
He explained that if the diagnosis is delayed, UTI may develop into a serious infection, which may have lasting consequences.
For example, kidney scarring associated with urinary tract infections is associated with hypertension and chronic kidney disease later in life.
For example, kidney scarring associated with urinary tract infections is associated with hypertension and chronic kidney disease later in life.
In order to diagnose a urinary tract infection, the doctor must culture a urine sample and wait for it to grow bacteria in a petri dish containing nutrients.
However, Nadeem said this process can take up to two days, delaying treatment.
Therefore, he and other doctors usually rely on testing for white blood cell-related proteins (called leukocyte esterase (LE)) in urine, and then identify them by looking for white blood cells (a marker of immune activity) in the urine.
The presence.
However, Nadeem said this process can take up to two days, delaying treatment.
Therefore, he and other doctors usually rely on testing for white blood cell-related proteins (called leukocyte esterase (LE)) in urine, and then identify them by looking for white blood cells (a marker of immune activity) in the urine.
The presence.
He added that in children, the number of white blood cells may be highly variable, and some of these changes may be caused by changes in urine concentration.
Therefore, it is not known which white blood cell count threshold should be used based on urine concentration to start treatment of potential UTI.
Therefore, it is not known which white blood cell count threshold should be used based on urine concentration to start treatment of potential UTI.
To determine these parameters, Nadeem and his colleagues searched the medical records of children under 24 months of age who were taken to the emergency room of the Children’s Medical Center between January 2012 and December 2017, suspected of having UTI, and Urine analysis was performed-in which the urine was evaluated for the concentration of LE and the presence of LE and white blood cells-and urine culture was performed.
The search found 24,171 patients, of which 2,003 were diagnosed with UTI based on urine culture.
The search found 24,171 patients, of which 2,003 were diagnosed with UTI based on urine culture.
Using the specific gravity of their urine (the density of the urine relative to water, as a proxy for concentration) and the number of white blood cells present in the field of high-power microscopy, the researchers came up with the critical point of urine.
Three urine concentration groups: For low urine concentration, children only need 3 white blood cells to suspect urinary tract infection; for medium concentration, the number is 6; for high concentration, it is 8.
Three urine concentration groups: For low urine concentration, children only need 3 white blood cells to suspect urinary tract infection; for medium concentration, the number is 6; for high concentration, it is 8.
Nadeem said that for each concentration group, the white blood cell esterase remained constant-suggesting that this is a good trigger for analyzing the presence of white blood cells in the urine.
He added that understanding how many white blood cells are often present in the urine of different concentrations of urine in children with urinary tract infections can help doctors start treating these infections before they become infected.
This can reduce the burden on patients and their parents and prevent complications.
disease.
Nadeem said: "The sooner we start treatment, the better for these young patients.
" "Our results add more information to the physician's toolbox to make this decision.
" (Bioon.
com)
This can reduce the burden on patients and their parents and prevent complications.
disease.
Nadeem said: "The sooner we start treatment, the better for these young patients.
" "Our results add more information to the physician's toolbox to make this decision.
" (Bioon.
com)
Information source: com/news/2021-03-treatment-urinary-tract-infections-children.
html">Speeding treatment for urinary tract infections in children
html">Speeding treatment for urinary tract infections in children
Original source: Shahid Nadeem et al.
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
In order to diagnose a urinary tract infection, the doctor must culture a urine sample and wait for it to grow bacteria in a petri dish containing nutrients.
However, Nadeem said this process can take up to two days, delaying treatment.
Therefore, he and other doctors usually rely on testing for white blood cell-related proteins (called leukocyte esterase (LE)) in urine, and then identify them by looking for white blood cells (a marker of immune activity) in the urine.
The presence.
However, Nadeem said this process can take up to two days, delaying treatment.
Therefore, he and other doctors usually rely on testing for white blood cell-related proteins (called leukocyte esterase (LE)) in urine, and then identify them by looking for white blood cells (a marker of immune activity) in the urine.
The presence.
He added that in children, the number of white blood cells may be highly variable, and some of these changes may be caused by changes in urine concentration.
Therefore, it is not known which white blood cell count threshold should be used based on urine concentration to start treatment of potential UTI.
Therefore, it is not known which white blood cell count threshold should be used based on urine concentration to start treatment of potential UTI.
To determine these parameters, Nadeem and his colleagues searched the medical records of children under 24 months of age who were taken to the emergency room of the Children’s Medical Center between January 2012 and December 2017, suspected of having UTI, and Urine analysis was performed-in which the urine was evaluated for the concentration of LE and the presence of LE and white blood cells-and urine culture was performed.
The search found 24,171 patients, of which 2,003 were diagnosed with UTI based on urine culture.
The search found 24,171 patients, of which 2,003 were diagnosed with UTI based on urine culture.
Using the specific gravity of their urine (the density of the urine relative to water, as a proxy for concentration) and the number of white blood cells present in the field of high-power microscopy, the researchers came up with the critical point of urine.
Three urine concentration groups: For low urine concentration, children only need 3 white blood cells to suspect urinary tract infection; for medium concentration, the number is 6; for high concentration, it is 8.
Three urine concentration groups: For low urine concentration, children only need 3 white blood cells to suspect urinary tract infection; for medium concentration, the number is 6; for high concentration, it is 8.
Nadeem said that for each concentration group, the white blood cell esterase remained constant-suggesting that this is a good trigger for analyzing the presence of white blood cells in the urine.
He added that understanding how many white blood cells are often present in the urine of different concentrations of urine in children with urinary tract infections can help doctors start treating these infections before they become infected.
This can reduce the burden on patients and their parents and prevent complications.
disease.
Nadeem said: "The sooner we start treatment, the better for these young patients.
" "Our results add more information to the physician's toolbox to make this decision.
" (Bioon.
com)
This can reduce the burden on patients and their parents and prevent complications.
disease.
Nadeem said: "The sooner we start treatment, the better for these young patients.
" "Our results add more information to the physician's toolbox to make this decision.
" (Bioon.
com)
Information source: com/news/2021-03-treatment-urinary-tract-infections-children.
html">Speeding treatment for urinary tract infections in children
html">Speeding treatment for urinary tract infections in children
Original source: Shahid Nadeem et al.
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
He added that in children, the number of white blood cells may be highly variable, and some of these changes may be caused by changes in urine concentration.
Therefore, it is not known which white blood cell count threshold should be used based on urine concentration to start treatment of potential UTI.
Therefore, it is not known which white blood cell count threshold should be used based on urine concentration to start treatment of potential UTI.
To determine these parameters, Nadeem and his colleagues searched the medical records of children under 24 months of age who were taken to the emergency room of the Children’s Medical Center between January 2012 and December 2017, suspected of having UTI, and Urine analysis was performed-in which the urine was evaluated for the concentration of LE and the presence of LE and white blood cells-and urine culture was performed.
The search found 24,171 patients, of which 2,003 were diagnosed with UTI based on urine culture.
The search found 24,171 patients, of which 2,003 were diagnosed with UTI based on urine culture.
Using the specific gravity of their urine (the density of the urine relative to water, as a proxy for concentration) and the number of white blood cells present in the field of high-power microscopy, the researchers came up with the critical point of urine.
Three urine concentration groups: For low urine concentration, children only need 3 white blood cells to suspect urinary tract infection; for medium concentration, the number is 6; for high concentration, it is 8.
Three urine concentration groups: For low urine concentration, children only need 3 white blood cells to suspect urinary tract infection; for medium concentration, the number is 6; for high concentration, it is 8.
Nadeem said that for each concentration group, the white blood cell esterase remained constant-suggesting that this is a good trigger for analyzing the presence of white blood cells in the urine.
He added that understanding how many white blood cells are often present in the urine of different concentrations of urine in children with urinary tract infections can help doctors start treating these infections before they become infected.
This can reduce the burden on patients and their parents and prevent complications.
disease.
Nadeem said: "The sooner we start treatment, the better for these young patients.
" "Our results add more information to the physician's toolbox to make this decision.
" (Bioon.
com)
This can reduce the burden on patients and their parents and prevent complications.
disease.
Nadeem said: "The sooner we start treatment, the better for these young patients.
" "Our results add more information to the physician's toolbox to make this decision.
" (Bioon.
com)
Information source: com/news/2021-03-treatment-urinary-tract-infections-children.
html">Speeding treatment for urinary tract infections in children
html">Speeding treatment for urinary tract infections in children
Original source: Shahid Nadeem et al.
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
To determine these parameters, Nadeem and his colleagues searched the medical records of children under 24 months of age who were taken to the emergency room of the Children’s Medical Center between January 2012 and December 2017, suspected of having UTI, and Urine analysis was performed-in which the urine was evaluated for the concentration of LE and the presence of LE and white blood cells-and urine culture was performed.
The search found 24,171 patients, of which 2,003 were diagnosed with UTI based on urine culture.
The search found 24,171 patients, of which 2,003 were diagnosed with UTI based on urine culture.
Using the specific gravity of their urine (the density of the urine relative to water, as a proxy for concentration) and the number of white blood cells present in the field of high-power microscopy, the researchers came up with the critical point of urine.
Three urine concentration groups: For low urine concentration, children only need 3 white blood cells to suspect urinary tract infection; for medium concentration, the number is 6; for high concentration, it is 8.
Three urine concentration groups: For low urine concentration, children only need 3 white blood cells to suspect urinary tract infection; for medium concentration, the number is 6; for high concentration, it is 8.
Nadeem said that for each concentration group, the white blood cell esterase remained constant-suggesting that this is a good trigger for analyzing the presence of white blood cells in the urine.
He added that understanding how many white blood cells are often present in the urine of different concentrations of urine in children with urinary tract infections can help doctors start treating these infections before they become infected.
This can reduce the burden on patients and their parents and prevent complications.
disease.
Nadeem said: "The sooner we start treatment, the better for these young patients.
" "Our results add more information to the physician's toolbox to make this decision.
" (Bioon.
com)
This can reduce the burden on patients and their parents and prevent complications.
disease.
Nadeem said: "The sooner we start treatment, the better for these young patients.
" "Our results add more information to the physician's toolbox to make this decision.
" (Bioon.
com)
Information source: com/news/2021-03-treatment-urinary-tract-infections-children.
html">Speeding treatment for urinary tract infections in children
html">Speeding treatment for urinary tract infections in children
Original source: Shahid Nadeem et al.
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
Using the specific gravity of their urine (the density of the urine relative to water, as a proxy for concentration) and the number of white blood cells present in the field of high-power microscopy, the researchers came up with the critical point of urine.
Three urine concentration groups: For low urine concentration, children only need 3 white blood cells to suspect urinary tract infection; for medium concentration, the number is 6; for high concentration, it is 8.
Three urine concentration groups: For low urine concentration, children only need 3 white blood cells to suspect urinary tract infection; for medium concentration, the number is 6; for high concentration, it is 8.
Nadeem said that for each concentration group, the white blood cell esterase remained constant-suggesting that this is a good trigger for analyzing the presence of white blood cells in the urine.
He added that understanding how many white blood cells are often present in the urine of different concentrations of urine in children with urinary tract infections can help doctors start treating these infections before they become infected.
This can reduce the burden on patients and their parents and prevent complications.
disease.
Nadeem said: "The sooner we start treatment, the better for these young patients.
" "Our results add more information to the physician's toolbox to make this decision.
" (Bioon.
com)
This can reduce the burden on patients and their parents and prevent complications.
disease.
Nadeem said: "The sooner we start treatment, the better for these young patients.
" "Our results add more information to the physician's toolbox to make this decision.
" (Bioon.
com)
Information source: com/news/2021-03-treatment-urinary-tract-infections-children.
html">Speeding treatment for urinary tract infections in children
html">Speeding treatment for urinary tract infections in children
Original source: Shahid Nadeem et al.
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
Nadeem said that for each concentration group, the white blood cell esterase remained constant-suggesting that this is a good trigger for analyzing the presence of white blood cells in the urine.
He added that understanding how many white blood cells are often present in the urine of different concentrations of urine in children with urinary tract infections can help doctors start treating these infections before they become infected.
This can reduce the burden on patients and their parents and prevent complications.
disease.
Nadeem said: "The sooner we start treatment, the better for these young patients.
" "Our results add more information to the physician's toolbox to make this decision.
" (Bioon.
com)
This can reduce the burden on patients and their parents and prevent complications.
disease.
Nadeem said: "The sooner we start treatment, the better for these young patients.
" "Our results add more information to the physician's toolbox to make this decision.
" (Bioon.
com)
Information source: com/news/2021-03-treatment-urinary-tract-infections-children.
html">Speeding treatment for urinary tract infections in children
html">Speeding treatment for urinary tract infections in children
Original source: Shahid Nadeem et al.
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
He added that understanding how many white blood cells are often present in the urine of different concentrations of urine in children with urinary tract infections can help doctors start treating these infections before they become infected.
This can reduce the burden on patients and their parents and prevent complications.
disease.
Nadeem said: "The sooner we start treatment, the better for these young patients.
" "Our results add more information to the physician's toolbox to make this decision.
" (Bioon.
com)
This can reduce the burden on patients and their parents and prevent complications.
disease.
Nadeem said: "The sooner we start treatment, the better for these young patients.
" "Our results add more information to the physician's toolbox to make this decision.
" (Bioon.
com)
Information source: com/news/2021-03-treatment-urinary-tract-infections-children.
html">Speeding treatment for urinary tract infections in children
html">Speeding treatment for urinary tract infections in children
Original source: Shahid Nadeem et al.
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
Information source: com/news/2021-03-treatment-urinary-tract-infections-children.
html">Speeding treatment for urinary tract infections in children
Information source: com/news/2021-03-treatment-urinary-tract-infections-children. html">Speeding treatment for urinary tract infections in children
Original source: Shahid Nadeem et al.
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
html">Speeding treatment for urinary tract infections in children
Original source: Shahid Nadeem et al.
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
Original source: Shahid Nadeem et al.
aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
Original Source: aappublications. aappublications.
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children , Pediatrics (2021).
DOI: 10.
1542/peds.
2020-014068
org/content/147/2/e2020014068">Pyuria and Urine Concentration for Identifying Urinary Tract Infection in Young Children Pediatrics
