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Phytomedicine: Preventive effect of Huoxiangzhengqi prescription on lipopolysaccharide-induced inflammatory response

 Last Update: 2022-05-08
 Source: Internet
 Author: User

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Background: Huoxiangzhengqi Oral Liquid (HX) originated from Huoxiangzhengqi Powder in "Taiping Huimin Hejiju" in Song Dynasty, and has been widely used in gastrointestinal diseases

Huoxiangzhengqi Oral Liquid (HX) Huoxiangzhengqi Oral Liquid (HX) Gastrointestinal Diseases Gastrointestinal Diseases Anti -inflammatory Immunomodulation Immune Infection Multi-direction and Multi-target

Objective: To investigate whether HX pretreatment can prevent lipopolysaccharide (LPS)-induced adverse reactions and its possible mechanism

prevention

Methods: 7-week-old male C57BL/6J mice were intragastrically administered low-dose (1.

HE staining, AB-PAS staining, TBO staining, qRT-PCR detection, Western blotting, ELISA, 16S ribosomal RNA gene sequencing analysis

RESULTS: The data showed that both low and high doses of HX significantly reduced LPS-induced inflammation

The richness and uniformity of gut microbiota at the level of inflammation HX pretreatment is not effective in preventing dysbiosis of the NF-κB pathway

Conclusion: This study demonstrates for the first time that the preventive effect of HX on LPS is mainly achieved by inhibiting inflammation

suppress inflammation suppress inflammation

Source:

Gao M, Zou Z, Qiu Y, et al.

Gao M, Zou Z, Qiu Y, et al.
Preventive effects of traditional Chinese medicine formula Huoxiangzhengqi against lipopolysaccharide-induced inflammatory response [published online ahead of print, 2022 Jan 29].
Phytomedicine.
2022;99:153968.
doi:10.
1016/ j.
phymed.
2022.
153968

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