Plos Med: Prevent type 1 diabetes, vitamin D supplementation is not reliable!

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A large number of observational studies have shown that vitamin D deficiency is related to type 1 diabetes , but there is a lack of evidence from randomized controlled trials.

A large number of observational studies have shown that vitamin D deficiency is related to type 1 diabetes , but there is a lack of evidence from randomized controlled trials.

Plos Medicine Vitamin D levels and risk of type 1 diabetes: A Mendelian randomization study shows that the reduction of vitamin D content will not significantly increase the risk of type 1 diabetes in the study population through Mendelian randomization study .

Mendelian randomization is a common method in the study of genetic epidemiology, which uses the measured variation in disease-related genes to examine the causal relationship between phenotype and disease.

The prevalence of type 1 diabetes is increasing at a rate of 3% per year among adolescents under the age of 14 worldwide.

The prevalence of type 1 diabetes is increasing at a rate of 3% per year among adolescents under the age of 14 worldwide.

The link between vitamin D and type 1 diabetes may be mediated by the effect of vitamin D on the immune system.

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But given that these findings are evidence from randomized controlled trials (RCTs),

A small prospective study of 252 children showed that there was no difference in 25OHD levels in children diagnosed with type 1 diabetes compared with controls.

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The effect of 25OHD on type 1 diabetes, Mendelian randomization forest plot

The effect of 25OHD on type 1 diabetes, Mendelian randomization forest plot

Another study showed that compared with children who were newly diagnosed with type 1 diabetes, their 25OHD levels were no different from their siblings.

The effect of 25OHD on type 1 diabetes, Mendelian randomization method scatter plot

The effect of 25OHD on type 1 diabetes, Mendelian randomization method scatter plot

A recent study of 1,316 children diagnosed with type 1 diabetes showed an unexpected inverse correlation between vitamin D intake and fasting C-peptide, which is a marker of residual insulin production in pancreatic β-cells.

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This finding does not support the large effect of vitamin D levels on type 1 diabetes, but smaller effects may not be detected.

25OHD levels are unlikely to have a large impact on the risk of type 1 diabetes, but larger MRT studies or RCTs are needed to study small effects.

Original source:

Vitamin D levels and risk of type 1 diabetes: A Mendelian randomization study org/10.

Vitamin D levels and risk of type 1 diabetes: A Mendelian randomization study org/10.
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