Protein engineering helps to improve the effect of mRNA therapy

April 1, 2018 / BIOON / -- mRNA drugs are believed to help deliver therapeutic protein molecules According to a recent study published in the Journal of nuclear acid therapeutics, more stable and more active proteins can be obtained through the engineering design method, thus further improving the potential of mRNA therapy Specifically, some specific sequence design can improve the expression of target protein, the time of existence and enzyme activity (photo source: Com) the study is called "leveraging rational protein engineering to improve mRNA therapeutics" by romesh Subramanian and other colleagues from alexion pharmaceuticals in Cambridge, USA The researchers say the expression of the engineered specific protein sequence and its positive effect have been verified at the mouse level Sequence engineering design can improve the thermochemical stability and therapeutic activity of protein "The development of protein variants that improve their stability and activity can reduce the dosage of the drug, thereby alleviating the complications of the patients after the medication," said Graham C Parker, executive editor of the Department of pediatrics at Wayne State University School of medicine in the United States Information source: rational protein engineering can improve effectiveness of mRNA therapies