Redox Biol: Coagulation protein-fibrinogen in the body or potential anti-inflammatory effect

In the paper, the researchers describe how fibrinogen plays a protective role against hypochlorite, a special chemical produced by the body during inflammation, and how it plays a key role in the plasma as a class of antioxidants.
Amy Wyatt says that when interacting with hychlorates, fibrinogens form very large aggregates so that they don't damage the body's cells like the perchlorate-modified albumin and exacerbate the symptoms of kidney and heart disease.
Although fibrinogens are not as rich as the main protein albumin in the blood, they are more likely to react with hychlorates in the body, and the accumulation of perchlorate-modified albumins in the body induces damage to the patient's body, however, chlorate-modified fibrinogens appear to be harmless to the health of the body, a study found that may ultimately help design new therapies to block the harmful effects of chlorate-modified white protein. in the
study, the researchers pinpointed the behavioral mechanisms of these different protein molecules, which they were able to use to block the disease-inducing effects of hyallorate-modified albumins, and they also mapped the normal functioning of protein molecules and the changes in their function when protein molecules were impaired by biological factors such as hyallorates.
findings are also expected to help scientists find new biomarkers that indicate a variety of inflammatory diseases.
original source: Noralyn Mañucat-Tana, Rafaa Zeineddine Abdallah, Harsimran Kaur, et al. Hypochlorite-induced aggregation of fibrinogen underlies a novel antioxidant role in blood plasma, Redox Biology (2020). DOI:10.1016/j.redox.2020.101847