Ren Fail: Iron deficiency is an important predictor of 5-year all-cause mortality in hemodialysis patients

Iron deficiency is common in patients with end-stage renal disease, especially those who require hemodialysis (HD)

Recently, "Renal Failure" published a clinical study aimed at investigating the relationship between iron, CACS and mortality in HD patients.

The study included 173 patients who continued to receive HD, and obtained laboratory data and Agatston's CACS of two groups of patients at baseline: patients with CACS ≥ 400 (n=109) and patients with CACS <400 (n=64) , The logistic regression analysis of mortality when CACS≥400 and the Cox proportional hazard analysis were performed later

The participants' median (interquartile range) age and duration of dialysis were 67 (60-75) years and 73 (37-138) months, respectively

TSAT≥17%, Fe≥63µg/dL and ferritin≥200ng/mL are important predictors of 5-year all-cause mortality in HD patients, independent of the conventional risk factors for all-cause mortality (p<0.

Kaplan-Meier 5-year cumulative survival curve of participants with transferrin saturation ≥17% and <17%

TSAT: Transferrin saturation

Kaplan-Meier 5-year cumulative survival curve of participants with serum iron ≥63 and <63µg/dL

Fe: serum iron

Scatter plot matrix of serum CRP, TSAT, Fe and ferritin of all participants

The study determined the association between iron, CACS and mortality in HD patients, and found that lower TSAT is an independent predictor of CACS ≥ 400, and iron deficiency (low TSAT, iron or ferritin) is a 5-year all-cause death in HD patients An important predictor of the rate