Rheumatic stomatism these drugs should be careful! Waist thickening, knee osteoarthritis may worsen? A week of wind and clouds.

Don't want to miss Jiemei's push? Click on the menu "··" in the upper right corner and select "set as star" for a week's information, waiting for you to see! What is the relationship between increased waist circumference and decreased body function in patients with knee osteoarthritis? What is the interaction between rheumatoid arthritis and psoriatic arthritis drugs? What factors are related to physical activity and sedentary behavior in patients with lower extremity osteoarthritis? 1. The waist circumference of knee osteoarthritis patients becomes thicker, what kind of influence does it have on body function? Knee osteoarthritis is a kind of chronic degenerative bone and joint disease, which seriously affects the quality of life of patients and has a certain disability rate, which brings huge burden to patients and families.the quality of life and physical function of patients with knee osteoarthritis are related to age, gender, body mass index (BMI), smoking, etc.but did you know that there is a certain correlation between waist circumference and physical function of patients with knee osteoarthritis.the researchers collected data from the Osteoarthritis Initiative (OAI), followed up for 96 months and measured changes in waist circumference.the patients were divided into two groups according to the WHO waist circumference risk classification: high waist circumference group (male ≥ 102CM, female ≥ 88cm) or small waist circumference group (male & lt; 102CM, female & lt; 88cm).observe the physical function of the patients.the results showed that the risk of decreased physical function in patients with increased waist circumference was 1.43 times higher than that in patients with waist circumference maintenance group.at baseline, the risk of decreased physical function was 1.55 times higher in the large waistline group than in the waist circumference maintenance group.at baseline, the risk of decreased physical function was 1.97 times higher in the small waistline group than in the maintenance group.for patients with knee osteoarthritis, there is a risk of decreased physical function in the second year after the increase in waist circumference, which may be reduced by maintaining the waist circumference, according to the researchers.therefore, it's very important to keep your waistline! The interaction of drugs in rheumatoid arthritis and psoriatic arthritis the treatment of rheumatoid arthritis (RA), psoriatic arthritis (PSA) and other inflammatory arthritis usually requires the use of three or more drugs at the same time.when multiple drugs are used at the same time, there will be certain interaction naturally. How do they affect patients with inflammatory arthritis? Scholars have carried on the analysis to this.▎ NSAID, PPI and NSAID are commonly used drugs in patients with inflammatory arthritis.because non selective NSAIDs such as diclofenac and ibuprofen have an increased risk of gastrointestinal bleeding, it is recommended that proton pump inhibitors (PPI) be co prescribed with non selective NSAIDs.the researchers did not find any clinically relevant interaction between NSAID and PPI. There is interaction between NSAID and glucocorticoid.their simultaneous use will increase the risk of gastrointestinal bleeding. When using glucocorticoids, the short-term intake of NSAIDs will cause gastric ulcer.both COX-2 inhibitors and opioids can relieve pain. both drugs are metabolized by CYP2D6, which may lead to pharmacokinetic interaction. ▎ csdmards can interact with NSAID when they are used in combination. about 80% of methotrexate is excreted through glomerular filtration, while NSAID can inhibit glomerular filtration by inhibiting prostaglandin synthesis. The combination of NSAID and NSAID will produce pharmacokinetic interaction. the pharmacodynamic interaction between methotrexate and analgin can trigger blood related adverse events. there is a pharmacokinetic interaction between methotrexate and glucocorticoid. Glucocorticoid can inhibit the cell uptake of methotrexate, resulting in the decrease of the efficacy of methotrexate. researchers have found that long-term combination of methotrexate and glucocorticoid will increase liver toxicity in patients. in clinical practice, doctors often add folic acid to methotrexate treatment to reduce its side effects. ▎ the biological DMARD (bdmar) commonly used in rheumatology patients has tumor necrosis factor (TNF - α) inhibitors, including adalimumab, cetuximab, gollimumab, infliximab, etc., interleukin (IL) antagonists, including tochizumab, ezhizumab, and antibodies against T cells. liver enzyme elevation is a common side effect of methotrexate and may also occur during the treatment of TNF - α inhibitors. therefore, when methotrexate and TNF - α inhibitors are used together, it may increase the risk of hepatotoxicity. ▎ tsdmard is a typical target synthetic DMARD (tsdmard) in rheumatism, including tolfatib and baretinib. torfatinib can be metabolized by various CYP enzymes, especially CYP3A4. Therefore, drugs that inhibit the CYP3A4 pathway may interact with it. in PPI, lansoprazole had a strong inhibitory effect on CYP2C19, while pantoprazole had a small inhibitory effect on it. in patients with inflammatory arthritis, tolfatib is often used in combination with methotrexate, and there is no pharmacokinetic effect between methotrexate and tolfatib. the researchers stressed that it is very safe to treat inflammatory arthritis with drugs, but it is necessary to pay attention to the interaction between drugs and choose a more reasonable scheme. 3 which factors are related to physical activity and sedentary behavior in patients with lower extremity osteoarthritis? Hip and / or knee OA patients are inconvenient in physical activity, which will inevitably reduce the number of outdoor activities. In recent years, with the popularity of the Internet and the popularity of short videos, the concept of time has become more and more blurred in people's eyes. Many people sit in front of the screen for a day, and sitting for a long time is even more harmful for patients with hip and / or knee OA. the researchers analyzed physical activity (frequency, duration, intensity, type) and screen-based sedentary behavior in patients with hip and / or knee OA to determine predictors of both. 878 patients were followed up for 5 years, and their physical activity and sedentary behavior based on screen were determined by questionnaire survey. the duration of physical activity is related to gender. patients with impaired self-reported indicators and obese patients are usually low-intensity physical activity group and high-intensity physical activity group. male patients' age & lt; 60, single status (or = 1.5), obesity (or = 2.1), smoking (or = 2.0) and poor health were associated with screen based sedentary behavior. according to the researchers, men, age & lt; 60, single, obesity, smoking and poor health were all predictors of sedentary behavior based on screen, which were sociodemographic and had no clinical characteristics. according to the researchers, the frequency and type of physical activity can predict physical activity in patients with hip and / or knee OA, while clinical characteristics cannot predict screen based sedentary behavior. References: [1] Meredith B. Christiansen, Louise M et.al.The Association of an Increasing Waist Circumference and Risk of Incident Low Physical Function in Adults with Knee Osteoarthritis.The Journal of Rheumatology March 2020, jrheum.190876; DOI: Stephan Pflugbeil, Karin Böckl, Reinhold Pongratz.Drug interactions in the treatment of rheumatoid arthritis and psoriatic arthritis.Rheumatology International volume 40, pages511–521(2020)[3] Sarah Bitar, Abdou Y. Omorou, Aurélie Van Hoye, .Five-year evolution patterns of physical activity and sedentary behavior in patients with lower-limb osteoarthritis and their sociodemographic and clinical correlates.The Journal of Rheumatology March 2020, jrheum.190854; DOI: