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This article is converted Medicine original, reproduced please indicate the source Author: Cathy Introduction: In the novel coronavirus start of a pandemic, some people had already raised the question, that is, after infected with a new crown, the human body can keep long immunity .
Now, several new crown vaccines have been developed and marketed one after another, and many people have also asked the same question.
In fact, in this problem, immune memory plays a key role-the complex interaction between immune cells, antibodies, and signal transduction substances allows the human body to resist known pathogens again very effectively.
Recently, a research team at the University of Basel discovered that some immune cells residing in the lungs can provide immunity for a long time after a flu outbreak.
Experiments in mice have shown that these helper cells can enhance the immune response to reinfection through another strain of influenza virus.
This discovery may help develop more durable vaccines against rapidly mutating viruses.
In this study, researchers led by Professor Carolyn King of the Department of Biomedicine at the University of Basel have now identified a variety of immune cells in the lungs, which are the key to preventing influenza virus reinfection.
Moreover, the same may be true for the reinfection of other pathogens that cause respiratory diseases.
In mouse experiments, the researchers used single-cell RNA sequencing technology to characterize a group of memory T cells in the lung tissue, and they found that these cells would remain in the lungs for a long time after a flu attack.
The research team described these "resident helper cells" (T resident helper cells) in the journal Science Immunology.
Nivedya Swarnalekha, the first author of the study who resides in the organization, explained: “Previously, people knew relatively little about the memory T cells remaining in the tissue.
Previous studies have mostly focused on memory cells in blood and lymphatic tissues.
However, the human body retains a reservoir of these cells in the tissues affected by the infection, in case the same or similar pathogens may invade these tissues again.
"In this study, the researchers described two types of helper T cells
in the lungs.
In the case of reinfection, one of the types of helper T cells releases signal substances to fight pathogens.
Equip other immune cells with a more lethal "weapon.
"
Another type of helper T cell, previously found mainly in lymphoid tissue, is thought to be absent from lung tissue, but this study found that it can help Immune cells that produce antibodies (B cells) and are in close contact with them exist in the lungs.
Researchers have shown that these cells exist directly near the B cells that produce antibodies, which can cause a more effective immune response against different influenza viruses.
Long-term vaccines The starting point for protection David Schreiner, another lead author of this study, said: "These helper T cells may be the starting point for the development of a continuous protective influenza vaccine.
"He added that, for example, components that activate these helper T cells can be added to vaccines and promote their migration into tissues.
To this end, people need further research and development.
References: [1] https:/ /medicalxpress.
com/news/2021-01-immune-cells-lungs-virus-defense.
html [2] https://immunology.
sciencemag.
org/content/6/55/eabb6808 Today’s video content recommendation [Trailer] " "My 2020" Professor Junhua Xiao-the leader of the molecular genetics project of the Institute of Biological Science and Technology, Donghua University, focusing on genetics, molecular diagnosis, more exciting, so stay tuned!
Now, several new crown vaccines have been developed and marketed one after another, and many people have also asked the same question.
In fact, in this problem, immune memory plays a key role-the complex interaction between immune cells, antibodies, and signal transduction substances allows the human body to resist known pathogens again very effectively.
Recently, a research team at the University of Basel discovered that some immune cells residing in the lungs can provide immunity for a long time after a flu outbreak.
Experiments in mice have shown that these helper cells can enhance the immune response to reinfection through another strain of influenza virus.
This discovery may help develop more durable vaccines against rapidly mutating viruses.
In this study, researchers led by Professor Carolyn King of the Department of Biomedicine at the University of Basel have now identified a variety of immune cells in the lungs, which are the key to preventing influenza virus reinfection.
Moreover, the same may be true for the reinfection of other pathogens that cause respiratory diseases.
In mouse experiments, the researchers used single-cell RNA sequencing technology to characterize a group of memory T cells in the lung tissue, and they found that these cells would remain in the lungs for a long time after a flu attack.
The research team described these "resident helper cells" (T resident helper cells) in the journal Science Immunology.
Nivedya Swarnalekha, the first author of the study who resides in the organization, explained: “Previously, people knew relatively little about the memory T cells remaining in the tissue.
Previous studies have mostly focused on memory cells in blood and lymphatic tissues.
However, the human body retains a reservoir of these cells in the tissues affected by the infection, in case the same or similar pathogens may invade these tissues again.
"In this study, the researchers described two types of helper T cells
in the lungs.
In the case of reinfection, one of the types of helper T cells releases signal substances to fight pathogens.
Equip other immune cells with a more lethal "weapon.
"
Another type of helper T cell, previously found mainly in lymphoid tissue, is thought to be absent from lung tissue, but this study found that it can help Immune cells that produce antibodies (B cells) and are in close contact with them exist in the lungs.
Researchers have shown that these cells exist directly near the B cells that produce antibodies, which can cause a more effective immune response against different influenza viruses.
Long-term vaccines The starting point for protection David Schreiner, another lead author of this study, said: "These helper T cells may be the starting point for the development of a continuous protective influenza vaccine.
"He added that, for example, components that activate these helper T cells can be added to vaccines and promote their migration into tissues.
To this end, people need further research and development.
References: [1] https:/ /medicalxpress.
com/news/2021-01-immune-cells-lungs-virus-defense.
html [2] https://immunology.
sciencemag.
org/content/6/55/eabb6808 Today’s video content recommendation [Trailer] " "My 2020" Professor Junhua Xiao-the leader of the molecular genetics project of the Institute of Biological Science and Technology, Donghua University, focusing on genetics, molecular diagnosis, more exciting, so stay tuned!
