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    Home > Active Ingredient News > Blood System > "Stocking up" On April 9, 2020 Blood Research Select

    "Stocking up" On April 9, 2020 Blood Research Select

    • Last Update: 2020-06-24
    • Source: Internet
    • Author: User
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    The difference in the immune spectrum between chronic GvHD and advanced acute GvHDhttps://doi.org/10.1182/blood.20190031863 months after hematopoietic stem cell transplantation (HSCT), human transplantantite anti-host disease (GvHD) biology is complexRecently, researchers used biomarker studies to evaluate the immune spectrum of chronic GvHD (cGvHD) and advanced acute GvHD (L-aGvHD)302 children were recruited in the study, of whom 241 were assessed as (1) L-aGvHD, (2) cGvHD, (3) active L-aGvHD or cGvHD, and (4) no cHD/L-aGvHDSignificant marker differences after adjustment of clinical primary factors are defined as compliance with all three criteria: ROC AUC s 0.60; p-value of 0.05; effect ratio of 1.3 or .75Patients with only obvious characteristics but judged by the adjudication committee (non-NIH-CC) as cGvHD have an immune spectrum similar to that of NIH-CCBoth cGvHD and late-stage aGvHD migrated B cells decreased and the solute cell-based NK cells both increasedCGvHD has additional abnormalities, with an increase in activated T cells, infantH and Tc cells, loss of cd56brightNKreg cells, and increased ST2 and sCD13Prior to the 114th day, there were additional abnormalities in the active L-aGvHD's infantite, naive Treg group and cytokines, while the active cGvHD had an increase in PD-1-memory Treg cells and pD1 plus memory Treg cells's treatment of recurrent/incurable CLL/SLL
    https://doi.org/10.1182/blood.2018884940Bruton tyrosine kinase (BTK) targeted therapy can significantly improve the overall survival of patients with chronic lymphoblastic leukemia or small lymphoblastic leukemia (CLL/SLL)Acalabrutinib is an oral, highly selective BTK inhibitor that allows it to be taken twice a day due to its selectivityin this 1b/2 study, 134 patients with recurrent/refractive CL or SLL (median age 66 years old (range 42-85); median pre-treatment, 2 times with acalabrutinib (100 mg/day) in median treatment for 41 months (range 0.2-58) BtK occupancy rate stable patient rate (median value) as high as 97% The most common side effects (AEs) are mild-moderate diarrhea (52%) and headache (51%) AEs with level 3 and above (seen in patients with 5 percent) had neutrophildecline (14%), pneumonia (11%), hypertension (7%), anemia (7%) and diarrhea (5%) The incidence of atrial fibrillation and haemorrhage AEs (all grades) was 7% and 5%, respectively The overall mitigation rate of acalabrutinib (including partial lymphocyte growth) was 94%, and the median duration of the mitigation and non-progression survival (PFS) was not achieved regardless of genomic characteristics (del (11) (q22.3), del (17) (p13.1), complex nuclei or immunoglobulin heavy chain mutations Estimated 45 months PFS is 62% (95% CI, 51%-71%) BTK mutation sits at 6/9 (67%) during recurrence Patients 3 Acetyl salicylic acid prevents infection-related clotting disorders and tissue damage https://doi.org/10.1182/blood.2019002783 anti-platelet therapy has been proposed for the treatment of sepsis, a syndrome caused by an immune response disorder and inappropriate activation of clotting Acetyl salicylic acid (ASA) may be used as a potential treatment strategy to prevent infection-induced clotting disorders and associated tissue damage through a living microscope, researchers found that Staphylococcus aureus infection can lead to neutrophil collection in the liver, platelet aggregation, and release of neutrophil extracellular traps (NIs) Platelet aggregation and NET release were significantly reduced in mice pretreated with ASA or in animals treated with ASA after infection 3h In addition, the intravascular coagulation enzyme activity decreased and the rate of microvascular embolism decreased in mice treated by ASA in contrast to those infected with Staphylococcus aureus This inhibition of clotting is accompanied by lower LEVELs of ALT and AST in the plasma, suggesting less liver damage Finally, there was no difference in bacterial load (CFU/ml) between the liver, lungs and spleen groups, and the swallowing capacity of Kupffer cells was preserved after ASA treatment the role of the PF4-VWF-HIT antibody complex in the course of heparin-induced platelet reduction https://doi.org/10.1182/blood.2018881607 heparin-induced platelet reduction disorder (HIT) is a prethrombotic disease mediated by platelet factor 4 (PF4) and a complex between heparin or other polyanions, but the risk of thrombosis is higher than heparin exposure associated with other PF4 partners Recently, researchers found that the endothelial cells around the blood clot were attacked by HIT antibodies, but the binding site was not yet clear in this study, the researchers found that in a mobile endothelial microfluidic system, PF4 binds to multiple discrete sites on the surface of the extended vwF released by endothelial cells after photochemical damage HIT-like monoclonal antibodies KKO and HIT patient antibodies can identify PF4-VWF complexes, promoting the increase of thrombosis in platelet adhesion and microfluidic channels The adhesion of platelets to the PF4-VWF-HIT antibody complex is inhibited by antibodies that can be closed fcgRIIA or the glycoprotein Ib-IX complex on platelets Destroying the PF4-VWF-HIT antibody complex with drugs that block or close the VWF oligopoly reduces thrombosis in HIT mouse models CD49d promotes the progression of chronic lymphoblastic leukemia
    https://doi.org/10.1182/blood.2019003179 CD49d is a significant prognostice biomarker of chronic lymphocytic leukemia (CLL) The widely proven 30% CLL positive cell threshold divided CLL patients into two subgroups with different prognosticmes, without taking into account the expression pattern of CD49d in this study, the researchers analyzed 1630 CLL samples and found that about 20% of CLL cases (313) had CD49d twin peak expression, i.e cd49dpos subgroup and CD49dneg subgroup Unlike the highly stable CD49d expression observed in patients with cd49d-uniform CLL expression, the CLL sample of CD49d Twin Peaks showed higher variability, and the CD49dpos subgroup increased with the duration of treatment Cd49dpos subgroups in CLL patients with cPL expression from CD49d have higher proliferative levels than CD49dneg cells, are more common in bone marrow than in peripheral blood (PB) and PB CLL subgroups expressing CXCR4dim/CD5bright phenotypes, and are known to be rich in proliferator cells From a clinical perspective, CD49d Twin Peaks patients, regardless of whether the CD49dpos subgroup exceeded the 30% threshold, in the context of chemotherapy immunotherapy (1522 cases) and Irutinib (158 people) treatment are similar to CD49dpos CLL patients Source: MedSci Original
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