Surg Endosc: Symesterone reduces bloating and improves intestinal preparation.

Methylsiloxane, an auxiliary drug commonly used in intestinal preparation before colonoscopy, is not yet agreed on whether it should be recommended in standard intestinal preparation.
We conducted a systematic review and meta-analysis to determine the effects of symethystone on intestinal cleanliness, adenoma detection rate (ADR) and tolerance, and the results were published online in Surg Endosc.
researchers looked in the literature for a study comparing colon cleanliness in patients who received standard bowel preparation alone before colonoscopy and were used in a joint use with simesiloxone.
result of this is colon cleanliness, ADR and tolerance.
study included 16 randomized controlled trials, including 5,630 patients.
, polyethyl glycol (PEG) and polyethyl glycol (Simethicone) improved colon cleanliness (OR 1.48, CI 1.11 to 1.97, P s 0.008) compared to PEG alone.
improvement can be seen in the individual dosing (OR 1.83, CI 1.20 to 2.79, P s 0.005) rather than in sub-drugs (OR 1.32, CI 0.72 to 2.43, P s 0.38).
overall, methylsiloxane had no effect on ADR (OR 1.22, CI 0.81 to 1.83, P s 0.33), but in patients receiving a single drug, methylsiloxane significantly increased ADR (OR 1.96, CI 1.22 to 3.16, P s 0.005).
nausea (OR 0.96, CI 0.75 to 1.24, P s 0.75), vomiting (OR 1.00, CI 0.69 to 1.44, P s 0.99) and abdominal pain (OR 0.69, CI 0.40 to 1.18, P s 0.17) did not differ significantly between PEG and PEG-Syme silicone queues.
for bloating, the PEG queue is more likely to develop bloating than peG-west methyl silicone queues (OR 2.33, CI 1.70 to 3.20, P<0.00001).
, the results showed that methylsiloxane improved colon cleanliness and ADR; however, this improvement was not seen in patients receiving a subdose of PEG.
addition, methylsiloxane reduces bloating, but has no effect on nausea, vomiting and abdominal pain.
may be a useful intestinal preparation aid for patients who cannot accept a subdose of PEG.
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