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Systemic lupus erythematosus in childhood: hydroxychloroquine blood concentration and evaluation

 Last Update: 2022-10-02
 Source: Internet
 Author: User

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Childhood systemic lupus erythematosus (cSLE) is a chronic systemic autoimmune disease

After oral administration, HCQ is well absorbed and has an absolute bioavailability of 79%.

However, for the same administered dose, the blood concentration of HCQ shows high inter-individual variability

SLEDAI score as a function of blood HCQ concentration:

Methods: The blood concentration and effect

Demographic, biological, and disease characteristics of 55 patients:

Results: A total of 168 blood samples

Hydroxychloroquine recommended dose (mg/kg/day) to achieve blood concentrations greater than 750 ng/mL:

In summary, the researchers developed a blood concentration-effect relationship

References: Zahr N, Urien S, Funck-Brentano C, Vantomme H, Garcelon N, Melki I, Boistault M, Boyer O, Bader-Meunier B.

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