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It is estimated that more than 20% of all cancers are caused by the direct result of systemic low inflammation.
different inflammatory markers can stimulate cancer progression and enhance tumor invasion and metastasis in many cancers, including colorectal cancer (CRC).
, higher levels of inflammatory markers are also associated with cancer prognosmation associated with advanced diseases.
has been shown to reduce CRC risk and potential CRC recurrence rates with the use of nonsteroidal anti-inflammatory drugs, especially aspirin.
prevention or reversal of systemic mild inflammation is considered a relevant and promising way to improve CRC prognostication.
study looked at the relationship between levels of 25-hydroxyvitamin D 3 (25(OH)D 3) and inflammatory markers (IL10, IL8, IL6, TNF alpha, and hsCRP) in 2 years after CRC diagnosis.
researchers assessed patients' levels of 25 (OH) D 3 and inflammatory markers over a period of 6, 12 and 24 months from 798 patients who participated in two prospective cohort studies.
25 (OH)D 3 levels were assessed at each point in time through multiple linear regression analyses, as well as an association between individual inflammatory markers and inflammatory z-scores.
showed that higher levels of 25 (OH) D 3 were associated with lower levels of IL6 (beta-0.06, 95% CI -0.08 to -0.04) 6 months and 2 years after diagnosis.
addition, 25 (OH)D 3 levels were negatively associated with overall inflammatory z-scores at diagnosis and over a 2-year process (beta-0.17, 95% CI -0.25 to -0.08).
, over a two-year process, it was found that there was a significant negative correlation between the level of 25 (OH) D 3 and IL10.
in vivo analysis showed a negative correlation between 25 (OH) D 3 and IL10, IL6 and TNF alpha.
no statistically significant association was observed between 25 (OH)D 3 and IL8 and hsCRP levels.
, the researchers said, serum 25 (OH) D 3 levels were negatively associated with overall inflammatory z-scores, especially with IL6, within a few years of CRC diagnosis.
potential clinical significance because IL6 plays an important role in chronic inflammation and is also thought to stimulate cancer progression.
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