TAG: Use plateplate and lymphocyte ratios in blood routines to predict disease activity in crohn's disease patients

Crohn's disease (CD) is a chronic gastrointestinal inflammatory disease characterized by repeated alternating disease remissions and recurrences.
within 20 years of Crohn's disease diagnosis, about half of CD patients had intestinal complications, such as stenosis or fistula.
, close monitoring of disease activity throughout the disease of CD is essential.
currently, endoscopic healing is considered a major therapeutic target for CD because it reduces the risk of disease-related complications and subsequent hospitalization and surgery.
, however, endoscopy is invasive, time-consuming and expensive, and is considered the most unacceptable test for disease surveillance in CD patients.
, precise and reliable non-invasive alternative markers are needed to assess the severity of CD endoscope disease activity.
ideal non-invasive diagnostic markers should be simple, easy to obtain, inexpensive and accurate.
most commonly used markers are fecal calcium protein (FC), C-reactive protein (CRP), red blood cell seratement (ESR), and so on.
CRP levels and ESR are important acute stage markers of inflammation and have been shown to perform well in the active assessment of disease in CD patients.
recent evidence of significant abnormalities in the whole blood cell count (CBC) in CD patients.
many studies have found that some conventional CBC blood indicators, such as red blood cell distribution width, plate plate count, average plate plate volume, and plateboard production ratio (PCT), can be used as biomarkers to monitor disease activity in CD patients.
, the purpose of this study is to build a simple model to predict the healing of the mucous membranes in the patient's intestines.
researchers conducted a retrospective analysis of confirmed CD patients who received endoscopy at four third-level medical centers in China between 2016 and 2020.
simple endoscopic score of CDs, CBC parameters, C-reactive protein (CRP) levels, individual variable rates of red blood cell sedation, and fecal calcitonin (FC) were analyzed independently by different researchers.
then analyzed the correlation between the variables and the degree of mucosal healing in the patient's endoscope.
study included 882 eligible CD patients and conducted a total of 1,388 endoscopic examinations, with useful routine blood parameters and related indicators carefully collected by researchers.
researchers found that models using plateplate-to-lymphocyte percentage ratio (PLpR) had higher accuracy in identifying endoscopic remission (ER) patients, with a sub-curve area (AUC) of 0.785 (95 percent) CI): 0.784-0.787, equivalent to CRP (AUC: 0.775, 95% CI: 0.774-0.777).
note that patients with colon disease and a history of surgery had significantly higher APOCs than CRP.
addition, after combining FC and PLpR, the AAUC value of FC and PLpR increased to up to 0.892 (95% CI:0.890-0.894) to identify endoscopic mucous membrane healing.
study identified mucous membrane healing in CD patients based on CBC plateplates and lymphocyte percentages (PLpR) from CD patients.