The development of microbial fermentation engineering

How is microbial fermentation project developed? And China's microbial development should pay attention to what aspects, l microbial fermentation engineering refers to the use of modern engineering technology means, the use of certain functions of microorganisms, the production of useful products for human beings or directly apply micro-organisms to industrial production of a new technology, to the main content sesame includes: the selection of bacteria, the configuration of the medium, sterilization, expansion of culture and inoculation, fermentation process and product separation purification and so onAt present, microbial engineering has encountered unprecedented challenges in economic development, especially the rapid development of synthetic industrial machine agricultural bioengineering makes microbial engineering face challenges, but microbial fermentation engineering also has its own advantages, especially in medicine, chemical industry, food and so on"text-align:center;"img src""alt"""microbial fermentation engineering development" "the development of microbial fermentation engineering" title","microbial fermentation engineering has grown after a long period of natural fermentation, the beginning of the natural fermentation period, as early as thousands of years ago, our ancestors know the technology of brewing, vinegar, and so on, and the brewing industry is the earliest microbial engineeringIt wasn't until 1667 that the Dutchman Levinhawk invented the microscope, revealing the secrets of the microbial worldWith the discovery of microorganisms, in 1850-1880, Pasteur, France, discovered the principle of fermentation through experiments, realizing that fermentation was caused by microbial activityWith the gradual improvement of microbial culture technology, a new era of artificial control of microorganisms has been createdIt has been more than 100 years of history in the world to use microbial decomposition and metabolism for large-scale industrial productionTherefore, the creation of microbial pure culture technology is the first turning period of the development of microbial engineering fermentation technologyThe second turning point in the development of microbial engineering fermentation technology was discovered in 1929 by British bacteriologist Fleming, because penicillin-producing bacteria are aerobic, microbiologists on the basis of anaerobic fermentation technology, the successful introduction of ventilation and stirring and a set of sterile technology, the establishment of good gas fermentation ventilation mixing technologyIt greatly promotes the development of fermentation industry, so that organic acids, microbiotin, hormones, etccan be produced on a large scale by fermentation methodAt present, microbial fermentation engineering has been developed to the continuousization and automation of large fermentation tanks, based on mathematics, dynamics, chemical principles, etc., through the computer to achieve automatic control of fermentation process research, so that the fermentation process control is more reasonable, the corresponding new process, new equipment is also emergingSince the 1980s, with the continuous cross-cutting and penetration of disciplines, microbiologists began to use mathematics, dynamics, chemical engineering principles, computer technology to carry out comprehensive research on the fermentation process, making the control of fermentation process more reasonableIn some countries, it has been possible to automatically record and automatically control all parameters of the fermentation process, significantly increasing productivityaccording to the microbial fermentation engineering method can also be divided into three stages:first, agricultural manual processing:fermentation project originated from the family or workshop-style fermentation production (agricultural manual processing), and then learned from the chemical engineering to achieve industrial production (modern fermentation engineering), and finally returned to the real microbial life activities as the center of research, design and guidance of industrial fermentation production (modern fermentation engineering), into the ranks of biological engineeringsecond and modern fermentation engineering:primitive workshop-style fermentation production by virtue of the skills and experience passed down by ancestors to produce fermentation products, heavy manual labor, production scale is limited, it is difficult to achieve industrial productionTherefore, the fermentation industry's predecessors first sought to learn from chemical and chemical engineering, to agricultural chemistry and chemical engineering, the fermentation production process was standardized, with pumps and pipelines and other means of delivery instead of shoulder-to-shoulder human handling, with machine production instead of manual operation, the workshop-style fermentation production successfully pushed to the level of industrial productionThe combination of fermentation production and chemical and chemical engineering led to the first leap in fermentation productionthird and modern fermentation engineering:decades of practice of fermentation industrial production, people gradually realize that the fermentation industrial process is a dynamic biological process that changes over time (time-varying), nonlinear, multivariate input and output, and it is often difficult to achieve the desired effect by dealing with the problem of fermentation industrial production (especially large-scale production) according to the chemical engineering modelFrom the point of view of chemical engineering, the fermentation tank is also the reaction of the production of raw material fermentation, the microbial cells cultivated in the fermentation tank is only a catalyst, according to the orthodox thinking of chemical engineering, micro-organisms of course it is difficult to play their life-specific production potentialThus, the biological kernel (microbes) that go back to the workshop-style fermentation production technology, returnto the truth and have a new understanding of the properties of fermentation engineeringThe determination of the biological properties of fermentation engineering has given a clear direction to the development of fermentation engineering, which has entered the category of biological engineering"style"text-align: center;"img src""alt" "the development of microbial fermentation engineering" "the development of microbial fermentation engineering"microbial fermentation engineering has developed as a new industrial system, has been deeply into the production of various industries, such as industry, agriculture, mining, chemical, pharmaceutical, food, energy and environmental protection, in various industries, knowledge and technological innovation plays an increasingly important roleHowever, although China's microbial fermentation project has certain advantages, but there are still some shortcomings, so in order to develop china's modern economy, microbial fermentation engineering should make greater efforts