The reporter learned from Wuhan University that recently, the State Key Laboratory of Virology of Wuhan University and the Hubei Provincial Center for Disease Control and Prevention have made new progress in the research on the persistence and cross-protective activity of neutralizing antibodies in patients recovering from the new coronavirus.
According to reports, the researchers collected 248 serum samples from patients infected with the new crown virus in Wuhan after recovering one year, and conducted a series of studies
The study also found that the neutralizing antibodies in the serum of most recovered patients can effectively neutralize the wild and British strains of the new coronavirus (B.
Researchers said that this result suggests that there may be a broad-spectrum SARS-CoV-2 neutralizing epitope, which brings hope for the development of broad-spectrum neutralizing antibodies and a broad-spectrum new crown vaccine
The receptor binding domain (RBD) is a key region for virus-mediated invasion.
In summary, the study provides reliable evidence that the new coronavirus-specific neutralizing antibodies in most recovered patients in Wuhan can last for at least one year, and can effectively neutralize wild and British strains, but for some mutations Strains, especially South African strains and Indian strains, showed a significant decrease in their antibody neutralization ability
Based on the research results, the researchers further proposed to update the S protein amino acid sequence of the vaccine in a timely manner, rationally arrange the time for boosting immunization, or a more economical, feasible and scientific immunization strategy
The research results were recently published in "Innovation"
Related paper information: https://doi.
https://doi.
org/10.
1016/j.
xinn.
2021.
100181
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