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Copyright statement: Where this website indicates all the works of "Source: China Science News, Science Net, Science News Magazine", on March 19, "The Lancet" published the online work conducted by academician Wang Chen of the Chinese Academy of Engineering in Wuhan The first long-term sero-epidemiological follow-up survey revealed the dynamic changes of serum antibodies in patients with new crown infection.
The results of the survey showed that among 9542 subjects, 532 were positive for antibodies to the new coronavirus.
After correction, the positive rate for antibodies in the population was 6.
9%.
This shows that even after the outbreak, only a small proportion of the population was infected.
Among these antibody-positive people, 82% are asymptomatic infections, and only 40% have produced neutralizing antibodies (functional antibodies that can effectively fight the virus), and this part of the population only accounts for 2.
7% of the Wuhan population, which is enough to explain The population still generally lacks immunity to the new coronavirus, and it is necessary to prevent the recurrence of the pandemic.
The number of infections estimated by the positive rate of seroantibodies is higher than the number of confirmed cases.
This study was conducted after Wuhan was unblocked in April 2020.
All 13 districts under the jurisdiction of Wuhan were selected and a strict multi-stage cluster random sampling method was used to sample 3556 families.
Representative samples of 9542 residents were subjected to on-site questionnaires, throat swab nucleic acid, and serum neocoronavirus antibody tests, followed by follow-up in June and October-December.
It is reported that this is also a prospective long-term seroepidemiological follow-up survey with the longest observation time and the most follow-up times in the world so far.
Studies have shown that the positive rate of antibodies in women is higher than that in men, and the positive rate of antibodies in people aged 66 and above is higher than that of other age groups.
The positive rate of antibodies in medical staff is higher than in other occupations.
People who have been through the hospital.
In addition, the study also found that there is a big difference between the number of confirmed cases of new crown in all countries and regions of the world and the number of infections estimated from the sero-positive rate of the population.
In this regard, researchers believe that this is mainly because most of the new crown infections are asymptomatic and mildly ill, plus the psychology and behavior of the infected patients, the local virus nucleic acid detection capabilities at the time of the epidemic, nucleic acid screening strategies, and nucleic acid sampling.
Differences in methods and laboratory testing methods have resulted in the antibody positive rate being much higher than the local incidence rate, and the number of infections calculated based on the sero-antibody positive rate is also much higher than the number of diagnosed cases.
"Assessing the proportion of people who are infected with the new coronavirus and who are immune is essential for formulating effective disease prevention and control strategies to reduce the possibility of recurring pandemics in the future.
" Wang Chen said, because people with mild infections may not seek medical attention.
Symptoms are usually not tested, and the number of confirmed cases of new crowns and the actual number of infections will be very different.
This is also a common phenomenon in the global new crown epidemic.
Neutralizing antibodies can be maintained for at least 9 months.
It is worth noting that 437 (82%) of the 532 new coronavirus antibody-positive patients in this study are asymptomatic, which is much higher than the estimated 40%-45% of global reports in the past.
value.
This also truly reflects a population infection characteristic of the new coronavirus and shows the "cunning" of the new coronavirus.
The researchers pointed out that the subjects may have recall bias when reporting whether they have had symptoms in the past 5 months, but this study will not obviously misjudge whether there are symptoms or not, because Wuhan took very strict measures to identify each case at that time.
Citizens also paid great attention to recording their symptoms during the outbreak.
"If the seroconversion rate can accurately reflect the exposure to the new coronavirus, then the obvious difference between the low number of cases and the high seroconversion rate indicates that most of the seroconversion rate is anti-new coronavirus antibodies produced by asymptomatic infection.
. "Relevant researchers said that they used live virus micro-neutralization test methods to ensure the accuracy of neutralizing antibody detection.
The
study found that in April 2020, only 40% (212/532 people) of antibody-positive people had neutralized Antibodies (functional antibodies that can effectively fight the virus).
After a dynamic follow-up, the proportion of people with neutralizing antibodies did not see a significant drop during the two follow-up periods: 45% in June 2020 (162/363 people); 2020 From October to December of the year, it was 41% (187/454 people).
In addition, the neutralizing antibody analysis of 335 participants who participated in all three follow-ups revealed that the level of neutralizing antibody did not decrease significantly within 9 months.
Chinese Academy of Medical Sciences Ren Lili, a researcher at the Institute of Pathogenic Biology of Peking Union Medical College, said that the durability of the immune response to the natural infection of the new crown virus is currently unclear.
"Our research has found that the antibodies produced after infection with the new crown virus can persist for more than 9 months.
Most importantly, we found that the neutralizing antibody remained stable for at least 9 months.
This phenomenon has guiding value for future precision prevention and control work.
"The above authoritative research conclusions based on the most severe front-line actual situation of epidemic prevention show that the industry consensus on the new coronary pneumonia at the beginning of the epidemic, self-limiting disease, mainly mild disease, low mortality, etc.
, has been confirmed again.
Of course, the beginning of the epidemic Suddenly, when the trend is not clear enough, coupled with local panic, and a certain degree of medical run, all localities attach great importance to it and adopt a series of top-tier tough control measures.
It is necessary, understandable, and the effect is indeed true.
Remarkable, attracting worldwide attention, and admired by the whole world.
The results of the survey showed that among 9542 subjects, 532 were positive for antibodies to the new coronavirus.
After correction, the positive rate for antibodies in the population was 6.
9%.
This shows that even after the outbreak, only a small proportion of the population was infected.
Among these antibody-positive people, 82% are asymptomatic infections, and only 40% have produced neutralizing antibodies (functional antibodies that can effectively fight the virus), and this part of the population only accounts for 2.
7% of the Wuhan population, which is enough to explain The population still generally lacks immunity to the new coronavirus, and it is necessary to prevent the recurrence of the pandemic.
The number of infections estimated by the positive rate of seroantibodies is higher than the number of confirmed cases.
This study was conducted after Wuhan was unblocked in April 2020.
All 13 districts under the jurisdiction of Wuhan were selected and a strict multi-stage cluster random sampling method was used to sample 3556 families.
Representative samples of 9542 residents were subjected to on-site questionnaires, throat swab nucleic acid, and serum neocoronavirus antibody tests, followed by follow-up in June and October-December.
It is reported that this is also a prospective long-term seroepidemiological follow-up survey with the longest observation time and the most follow-up times in the world so far.
Studies have shown that the positive rate of antibodies in women is higher than that in men, and the positive rate of antibodies in people aged 66 and above is higher than that of other age groups.
The positive rate of antibodies in medical staff is higher than in other occupations.
People who have been through the hospital.
In addition, the study also found that there is a big difference between the number of confirmed cases of new crown in all countries and regions of the world and the number of infections estimated from the sero-positive rate of the population.
In this regard, researchers believe that this is mainly because most of the new crown infections are asymptomatic and mildly ill, plus the psychology and behavior of the infected patients, the local virus nucleic acid detection capabilities at the time of the epidemic, nucleic acid screening strategies, and nucleic acid sampling.
Differences in methods and laboratory testing methods have resulted in the antibody positive rate being much higher than the local incidence rate, and the number of infections calculated based on the sero-antibody positive rate is also much higher than the number of diagnosed cases.
"Assessing the proportion of people who are infected with the new coronavirus and who are immune is essential for formulating effective disease prevention and control strategies to reduce the possibility of recurring pandemics in the future.
" Wang Chen said, because people with mild infections may not seek medical attention.
Symptoms are usually not tested, and the number of confirmed cases of new crowns and the actual number of infections will be very different.
This is also a common phenomenon in the global new crown epidemic.
Neutralizing antibodies can be maintained for at least 9 months.
It is worth noting that 437 (82%) of the 532 new coronavirus antibody-positive patients in this study are asymptomatic, which is much higher than the estimated 40%-45% of global reports in the past.
value.
This also truly reflects a population infection characteristic of the new coronavirus and shows the "cunning" of the new coronavirus.
The researchers pointed out that the subjects may have recall bias when reporting whether they have had symptoms in the past 5 months, but this study will not obviously misjudge whether there are symptoms or not, because Wuhan took very strict measures to identify each case at that time.
Citizens also paid great attention to recording their symptoms during the outbreak.
"If the seroconversion rate can accurately reflect the exposure to the new coronavirus, then the obvious difference between the low number of cases and the high seroconversion rate indicates that most of the seroconversion rate is anti-new coronavirus antibodies produced by asymptomatic infection.
. "Relevant researchers said that they used live virus micro-neutralization test methods to ensure the accuracy of neutralizing antibody detection.
The
study found that in April 2020, only 40% (212/532 people) of antibody-positive people had neutralized Antibodies (functional antibodies that can effectively fight the virus).
After a dynamic follow-up, the proportion of people with neutralizing antibodies did not see a significant drop during the two follow-up periods: 45% in June 2020 (162/363 people); 2020 From October to December of the year, it was 41% (187/454 people).
In addition, the neutralizing antibody analysis of 335 participants who participated in all three follow-ups revealed that the level of neutralizing antibody did not decrease significantly within 9 months.
Chinese Academy of Medical Sciences Ren Lili, a researcher at the Institute of Pathogenic Biology of Peking Union Medical College, said that the durability of the immune response to the natural infection of the new crown virus is currently unclear.
"Our research has found that the antibodies produced after infection with the new crown virus can persist for more than 9 months.
Most importantly, we found that the neutralizing antibody remained stable for at least 9 months.
This phenomenon has guiding value for future precision prevention and control work.
"The above authoritative research conclusions based on the most severe front-line actual situation of epidemic prevention show that the industry consensus on the new coronary pneumonia at the beginning of the epidemic, self-limiting disease, mainly mild disease, low mortality, etc.
, has been confirmed again.
Of course, the beginning of the epidemic Suddenly, when the trend is not clear enough, coupled with local panic, and a certain degree of medical run, all localities attach great importance to it and adopt a series of top-tier tough control measures.
It is necessary, understandable, and the effect is indeed true.
Remarkable, attracting worldwide attention, and admired by the whole world.
