The Lancet Rheumatology: Clinical and molecular characteristics related to the outcome of acute knee injury after 2 years: Results from the Longitudinal Study (KICK) of the Kennedy Knee Injury Cohort

Joint damage is the main risk factor for osteoarthritis, which provides an opportunity to prospectively explore the early stages of osteoarthritis
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This article investigates whether predefined baseline demographic and clinical factors, as well as knee synovial fluid and proteins in plasma or serum are related to clinical outcomes 2 years after knee injury

Baseline demographic and clinical factors, as well as whether knee synovial fluid and plasma or serum proteins are related to clinical outcomes 2 years after knee injury

This longitudinal cohort study recruited patients aged 16-50 years from six hospitals and clinics in London, UK between November 1, 2010 and November 28, 2014
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The subject had a severe acute knee joint injury (effusion and structural damage on MRI) within 8 weeks, which was treated with surgery

Immunity _{4 4}

The study included 150 patients, and the median time after knee injury was 17 days (range 1-59 days, interquartile range 9-26 days)
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123 (82%) were male, with a median age of 25 years (range 16-50 years, interquartile range 21-30 years)

_{4 4} Baseline KOOS ₄ , moderate to large knee joint effusion, moderate to severe synovial blood staining and their interaction significantly predict KOOS at 2 years _{4 4 4 4} biomarkers, combined with the interaction of joint effusion and blood staining, can explain 39 % Result variability

 

Conclusion: Joint effusion and hemorrhage are significantly related to the symptomatic outcome after acute knee injury
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Synovial molecular protein changes after acute knee injury (the best representatives are MCP-1 and IL-6) are independently related to symptomatic outcomes, but not to structural outcomes

Conclusion: Joint effusion and hemorrhage are significantly related to the symptomatic outcome after acute knee injury.

Garriga C, Goff M, Paterson E, Hrusecka R, Hamid B, Alderson J, Leyland K, Honeyfield L, Greenshields L, Satchithananda K, Lim A, Arden NK, Judge A, Williams A, Vincent TL, Watt FE.

Garriga C, Goff M, Paterson E, Hrusecka R, Hamid B, Alderson J, Leyland K, Honeyfield L, Greenshields L, Satchithananda K, Lim A, Arden NK, Judge A, Williams A, Vincent TL, Watt FE.
Clinical and molecular associations with outcomes at 2 years after acute knee injury: a longitudinal study in the Knee Injury Cohort at the Kennedy (KICK).
Lancet Rheumatol.
2021 Jun 24;3(9):e648-e658.
doi: 10.
1016/S2665-9913 (21)00116-8.
PMID: 34476411; PMCID: PMC8390381.
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