The Lancet: Sitting for more than 6 hours a day brings 12 chronic diseases to your door!

Given its high prevalence and health costs, sitting is a major public health concern

Given its high prevalence and health costs, sitting is a major public health concern

Current guidelines and overviews systematically summarize the evidence on the effects of sedentary time on health outcomes

To strengthen existing evidence on the effects of sedentary time and to inform the development and evaluation of physical activity interventions, this study explored the combined associations of sedentary time with risk of 45 noncommunicable diseases, with the primary objective of assessing the use of mild Whether high-level physical activity (LPA), moderate physical activity (MPA), vigorous physical activity (VPA), and sleep-replacing sedentary time per day are associated with reduced risk of certain noncommunicable diseases

To strengthen existing evidence on the effects of sedentary time and to inform the development and evaluation of physical activity interventions, this study explored the combined associations of sedentary time with risk of 45 noncommunicable diseases, with the primary objective of assessing the use of mild Whether high-level physical activity (LPA), moderate physical activity (MPA), vigorous physical activity (VPA), and sleep-replacing sedentary time per day are associated with reduced risk of certain noncommunicable diseases

The study ultimately included 360,047 participants (54.

The study ultimately included 360,047 participants (54.

Estimated dose-response associations between sedentary time and individual NCDs were derived from restricted cubic spline models, and sedentary time overall was associated with risk for 17 NCDs

Estimated dose-response associations between sedentary time and individual NCDs were derived from restricted cubic spline models, and sedentary time overall was associated with risk for 17 NCDs

When sedentary time was classified, compared with sedentary time ≤2 hours/day, >6 hours/day was found to be associated with higher risk for 12 of 45 NCDs ( P<0.

The researchers estimated PAF for noncommunicable diseases that were significantly associated with sedentary time (Figure 2)

The researchers estimated PAF for noncommunicable diseases that were significantly associated with sedentary time (Figure 2)

The results of the ISM inspection are shown in Table 2

The results of the ISM inspection are shown in Table 2

In contrast, replacing 1 hour of sedentary time per day with an equivalent VPA was associated with 6 types of 10 NCDs (diabetes, chronic kidney disease, chronic obstructive pulmonary disease, diverticular disease, depression, chronic liver disease, IHD, Lung cancer, IBD, and sleep disturbances) were associated with lower risks, with relatively larger declines ranging from 7% to 19%

Although different daily sedentary times were substituted with equal amounts of physical activity, the study found that replacing sedentary time with LPA, MPA, and VPA had a linear effect on several NCDs

Participants who reported >6 hours/day were at higher risk for 45 NCDs, including ischaemic heart disease, diabetes, chronic obstructive pulmonary disease, asthma, compared with ≤2 hours/day of sedentary time, Chronic kidney disease, chronic liver disease, thyroid disease, depression, migraine, gout, rheumatoid arthritis and diverticulosis
.
Theoretically, replacing sedentary time with equivalent LPA, MPA, and VPA was associated with a reduced risk of 4, 6, and 10 NCDs, respectively
.
Replacing 1 hour/day of sedentary time with equivalent VPA in prolonged sedentary time (>6 hours/day) was associated with 5 NCDs (diabetes, depression, chronic liver disease, diverticulosis, and sleep disturbance) The correlation was stronger, with an 11%-31% lower risk
.

Participants who reported >6 hours/day were at higher risk for 45 NCDs, including ischaemic heart disease, diabetes, chronic obstructive pulmonary disease, asthma, compared with ≤2 hours/day of sedentary time, Chronic kidney disease, chronic liver disease, thyroid disease, depression, migraine, gout, rheumatoid arthritis and diverticulosis
.
Theoretically, replacing sedentary time with equivalent LPA, MPA, and VPA was associated with a reduced risk of 4, 6, and 10 NCDs, respectively
.
Replacing 1 hour/day of sedentary time with equivalent VPA in prolonged sedentary time (>6 hours/day) was associated with 5 NCDs (diabetes, depression, chronic liver disease, diverticulosis, and sleep disturbance) The correlation was stronger, with an 11%-31% lower risk
.

This comprehensive analysis, based on a large prospective study in the UK, showed linear dose-response associations between sedentary time and 14 types of non-communicable diseases, providing evidence for the harmful effects of sitting
.
The study found that sedentary time >6 hours/day was associated with an increased risk of 12 of 45 NCDs, statistically independent of physical activity and sleep
.
Replacing sedentary time with an equivalent VPA reduces the risk of more types of NCDs than LPA and MPA
.
Recommendations for sedentary time may suggest that any reduction in sedentary behavior coincides with an increase in time spent on healthier alternatives to ensure positive substitution effects
.
Further research is needed to investigate causality through experimental interventions
.

This comprehensive analysis, based on a large prospective study in the UK, showed linear dose-response associations between sedentary time and 14 types of non-communicable diseases, providing evidence for the harmful effects of sitting
.
The study found that sedentary time >6 hours/day was associated with an increased risk of 12 of 45 NCDs, statistically independent of physical activity and sleep
.
Replacing sedentary time with an equivalent VPA reduces the risk of more types of NCDs than LPA and MPA
.
Recommendations for sedentary time may suggest that any reduction in sedentary behavior coincides with an increase in time spent on healthier alternatives to ensure positive substitution effects
.
Further research is needed to investigate causality through experimental interventions
.

 

Original source:

Original source:

Zhi Cao, et al.
Associations of sedentary time and physical activity with adverse health conditions: Outcome-wide analyses using isotemporal substitution model.
eClinicalMedicine 2022;48: 101424 Published online xxx https://doi.
org/10.
1016/j.
eclinm.
2022.
101424.

Zhi Cao, et al.
Associations of sedentary time and physical activity with adverse health conditions: Outcome-wide analyses using isotemporal substitution model.
eClinicalMedicine 2022;48: 101424 Published online xxx https://doi.
org/10.
1016/j.
eclinm.
2022.
101424.


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