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There is such a "magic drug", which is used by about 150 million people around the world.
It has a variety of magical effects, but the drug price is not expensive - it is metformin
.
It has a variety of magical effects, but the drug price is not expensive - it is metformin
.
metformin
Metformin is not only one of the most widely used oral hypoglycemic drugs, but also new research shows that it has more than 20 kinds of effects, including, combined with other drugs can reduce the incidence of cancer, reduce the risk of heart disease, help Weight control, anti-aging and anti-inflammatory.
.
.
Previously, bioRxiv published a new study showing that metformin can even reduce the new coronavirus load in single cells!
.
.
Previously, bioRxiv published a new study showing that metformin can even reduce the new coronavirus load in single cells!Source: Network
Almost every month, "possible new effects" of metformin are discovered.
If you don't believe it, you can search for "metformin" on the Mays public account
.
Therefore, people in the medical field joked, "Metformin is no longer a medicine, but the key to open a new era of the universe"
Almost every month, "possible new effects" of metformin are discovered.
However, a recent study made the "magic medicine" miserable
A large cohort study conducted by researchers from the University of Southern Denmark in Denmark and Stanford University in the United States found that metformin in men taking metformin during sperm development (3 months before conception) was associated with an increased risk of birth defects, especially in boys.
https://doi.
org/10.
7326/M21-4389
org/10.
7326/M21-4389
Previous studies have found that some diabetes drugs may damage sperm quality and affect male reproductive health
.
Therefore, in this study, the researchers compared whether men taking different hypoglycemic drugs, including insulin, metformin, and sulfonylureas during sperm development, had differences in the risk of birth defects in offspring
Previous studies have found that some diabetes drugs may damage sperm quality and affect male reproductive health
The study included the postnatal development of 1,116,779 infants from Denmark from 1997-2016 whose mothers did not have diabetes or high blood pressure
It takes about 3 months to develop from prospermia to fully mature sperm
The data survey found that compared with the control group, the use of insulin by fathers to lower blood sugar did not increase the risk of neonatal birth defects (aOR=0.
98, [95% CI, 0.
85 to 1.
14])
.
However, offspring exposed to metformin had a higher rate of birth defects, with a 40% increased risk (aOR=1.
The data survey found that compared with the control group, the use of insulin by fathers to lower blood sugar did not increase the risk of hypoglycemia in newborns with birth defects (aOR=0.
Offspring exposed to sulfonylureas were associated with a 34% increased risk of birth defects (aOR=1.
So the researchers focused their attention on metformin
However, studies have shown that the use of metformin by fathers before or after sperm development does not increase the risk of birth defects in babies
.
It also did not affect the risk of birth defects in other siblings who were not exposed to metformin
.
.
It also did not affect the risk of birth defects in other siblings who were not exposed to metformin
.
Taken together, paternal use of metformin during sperm development was associated with a 40% increased risk of birth defects in newborns compared with other blood sugar-lowering drugs
.
Among them, the genital defects of male infants were the most affected, and the incidence was 3.
39 times that of the control group
.
.
Among them, the genital defects of male infants were the most affected, and the incidence was 3.
39 times that of the control group
.
This study is a reminder for expectant dads with diabetes
.
The "magic drug" metformin is also a double-edged sword.
During pregnancy, you should discuss with your doctor whether to replace the diabetes treatment plan, and weigh the pros and cons of replacing metformin with other drugs and life>
.
.
The "magic drug" metformin is also a double-edged sword.
During pregnancy, you should discuss with your doctor whether to replace the diabetes treatment plan, and weigh the pros and cons of replacing metformin with other drugs and life>
.
Of course, the researchers stress that the paper also has certain flaws
.
Previous studies have shown that diabetes also affects sperm quality, but this study did not take into account whether the father's diabetes was well controlled during sperm development
.
At the same time, more new drugs for the treatment of diabetes have not been included, and more in-depth research is needed
.
.
Previous studies have shown that diabetes also affects sperm quality, but this study did not take into account whether the father's diabetes was well controlled during sperm development
.
At the same time, more new drugs for the treatment of diabetes have not been included, and more in-depth research is needed
.
The so-called "drug is a three-point poison" and "a once-in-a-century anti-sugar drug" metformin also has both positive and negative sides, and it should be used with caution
.
.
Reference [1] Wensink MJ, Lu Y, Tian L, Shaw GM, Rizzi S, Jensen TK, Mathiesen ER, Skakkebæk NE, Lindahl-Jacobsen R, Eisenberg ML.
Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring : A Nationwide Cohort Study.
Ann Intern Med.
2022 Mar 29.
doi: 10.
7326/M21-4389.
Epub ahead of print.
PMID: 35344380.
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