The medical-engineering interdisciplinary research team of Prof. Qiu Wei from the Department of Ultrasound Medicine published a cover research paper on Advanced Materials, revealing that different metal active centers have...

Recently, Prof.

Cao Sujiao, a full-time postdoctoral fellow in the Department of Ultrasound Medicine of our hospital, is the first author of the paper.

Figure 1: Journal Cover

Nature has created a large number of biological enzymes to catalyze various biochemical reactions and biological processes

Since it is not possible to compare the catalytic activity, substrate selectivity, kinetics and reactive oxygen species (ROS) production of different M-Nx single-atom centers, and to analyze the related catalytic ROS production mechanism, etc.

Figure 2: Metalloprotease-like single-atom library materialscatalyzing the production of ROS

Figure 3: Structural characterization of transition metal single-atom enzyme mimics

Figure 4: Catalytic ROS production activityof single-atom enzyme-mimicking materials

Theoretical calculation results show that the catalytic pathway and activity of AMEs are closely related to the electronic structure of the metal active center

Figure 5: Pathway and theoretical analysis of catalytic ROS production activity

In this study, for the first time, 20 single-atom libraries of ROS-catalyzing metalloproteinases with regular nanocube morphology, consistent size and specific surface area but different metal centers were synthesized, and the enzyme centers of related single-atom materials were systematically analyzed and compared.

Original link: https://onlinelibrary.