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BEIJING, Aug. 25
Science and Technology Daily (Intern Gao Jian) According to the Nature website recently reported that through live experiments in laboratory animals, the United States and China two groups of researchers found that in the nasal cavity drip candidate new crown vaccine can play an immune effect, and may be more effective than traditional vaccination methods, is expected to be more efficient after the vaccine put into use, the social benefits can not be underestimated.
To conduct the nasal inoculation experiment, a team at the University of Washington School of Medicine designed a candidate vaccine that encodes the new coronavirus protrusion protein, which binds to host cells to complete the infection process. The researchers injected the vaccine into bioengineered mice with human subjects corresponding to the protein.
, after vaccination, no infectious virus was found in the lungs of mice exposed to the new coronavirus, but a small amount of viral RNA was indeed detected. In contrast, no viral RNA was detected in nasal vaccinated mice, and other evidence suggests that nasal vaccination can achieve full immunity.
At the same time, a team of researchers at the First Affiliated Hospital of Guangzhou Medical University conducted experiments on rhesus monkeys using another vaccine that encodes the new coronavirus prickly protein, and researchers found that nasal inoculation, like traditional injections, could have the same effect as preventing viral infections. At the end of the experiment, 9 bits of rhesus monkeys that received different doses of injection or nasal immunity were sampled and tested negative for viral nucleic acids. In contrast, high-volume viruses were detected at different locations in unvaccinated monkeys.
researchers say the discovery of nasal inoculation methods can make vaccination easier by allowing people to drip into the vaccine themselves, while the nasal immune method is expected to reduce the potential immune problems caused by the adenovirus vector itself and achieve better immune results.
