The new dispensing gel can respond to the onset of arthritis in mice

a mouse model published this week in the journal Nature-Communication
, showing an active release gel for diseases that respond to inflammatory arthritis.triglycerides (TG-18) are self-assembled to form arthritis-responsive hydrogels.
patients with inflammatory arthritis have a low activity, a while high, high time is also known as the onset of the disease. The treatment of drugs that transmit the same dose cannot cope with and adapt to these changes in activity, so optimal dosage may not be achieved during the cycle of disease activity.
Andrey Karp and colleagues at Bregan Women's Hospital in the United States are trying to address the mismatch between disease activity and drug dosage by developing a hydrogel that responds to seizures. In cells and mouse models of inflammatory arthritis, the gel breaks down when it comes into contact with arthritis-related enzymes. The gel can carry different small molecules that release a corresponding amount of the drug depending on the severity of the onset of the disease. A decrease in arthritis activity can be observed when the gel is loaded with a corticosteroid used to treat arthritis.。 The decomposition of TG-18 gels is associated with the severity of arthritis.
gels are a potentially effective treatment for inflammatory arthritis, according to the authors. But they caution that more research is needed to optimize the composition of the gel and that testing is necessary in large animals with human-sized joints before possible human clinical trials can be considered. This may be the first step in designing treatments that respond to disease activity, the authors conclude. (Source: Science.com)