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    Home > Active Ingredient News > Endocrine System > The patient has osteoporosis, which may also be caused by these 4 drugs

    The patient has osteoporosis, which may also be caused by these 4 drugs

    • Last Update: 2022-08-20
    • Source: Internet
    • Author: User
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    *For medical professional reading reference only


    Don't forget to ask the patient's medication history!


    Osteoporosis (OP) is a systemic bone metabolic disorder characterized by low bone mineral content, damage to bone microstructure, and reduced bone strength, resulting in increased bone fragility and susceptibility to fractures



    The anticoagulant - warfarin


    Warfarin can inhibit the carboxylation of osteocalcin and reduce bone calcium deposition, thereby interfering with bone metabolism, leading to osteoporosis or fractures, and the risk of long-term use is greater


    3.



    Thiazolidinediones (TZDs) are a new class of drugs that increase insulin sensitivity.


    The proton pump inhibitor - omeprazole


    Proton pump inhibitors (PPIs) are commonly used drugs for peptic ulcer.


    Summarize


    Drug-induced osteoporosis (DIO) seriously affects the quality of life of patients, easily causing falls, fractures and even life-threatening.



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    [3] Wang Xiaolei, Wang Weihong, Dong Xinhong.
    A systematic review of the effect of proton pump inhibitors on fracture risk [J].
    Chinese Journal of Evidence-Based Medicine, 2012, 12(2): 216-223.
    [4] Mazziotti G, CanalisE, Giustina A,et al.
    Drug-induced osteoporosis: mechanisms and clinicalimplications[J].
    Am J Med,2010,123(10):877-884.
    [5]Wang Rong,Li Li.
    Zoledronate in the treatment of osteoporosis Clinical Observation of Symptoms[J].
    Electronic Journal of Modern Medicine and Health Research,2018,2(7):84-84.
    [6]Home PD,Pocock SJ,Beck-Nielsen H,et al.
    Rosiglitazone evaluated for cardiovascular outcomes inoral agent Combination therapy for type 2 diabetes ( RECORD ): A multicentre, randomised, open-label trial.
    Lancet, 2009, DOI: 10.
    1016/S0140-6736(09)60953-3.
    [7] Hou Jianming, Li Jianwei, Lin Qingming, et al.
    Changes of bone mineral density in patients with type 2 diabetes mellitus complicated with peripheral vascular disease.
    Chinese Physician Journal.
    2006, 29(11): 46-48.
    [8] Zhao Liwei, Liu Gaifang, Wu Jing, etc.
    Long-term application of proton pump inhibitors in elderly patients affects bone density Research on the influence of porosity[J].
    Chongqing Medical Science, 2017, 46(13): 1768-1769.
    [9] Cai Ying, Cong Xu, Fei Ran.
    Effects of Helicobacter pylori, omeprazole and gastrin on proliferation and apoptosis of gastric mucosal epithelial cells.
    Chinese Medical Journal, 2010, 90(5): 2558-2563
    This article was first publishedResponsible Editor of Drug Evaluation CenterCao Qian

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