The signaling pathway of traditional Chinese medicine to promote the healing of diabetic wounds

Diabetes mellitus (DM) has a serious impact on global human health due to changes in life>
.

As of 2019, there were 463 million people with diabetes worldwide

As of 2019, there were 463 million people with diabetes worldwide

At present, it has been found that Chinese herbal medicine compounds and active ingredients can effectively promote the healing of diabetic wounds, and the mechanism of action needs to be further studied

The main mechanisms of the occurrence and recurrence of diabetic wounds:

Materials and methods: Using "diabetic wound", "diabetic foot ulcer", "traditional Chinese medicine", "natural plant", "medicinal plant" as the main keywords, PubMed, Web of Science, CNKI, other publication resources, used for Search literature
.

Materials and Method:

The results showed that traditional Chinese medicine can regulate the signaling pathways that promote the healing of diabetic wounds, such as Wnt, Nrf2/ARE, MAPK, PI3K/Akt, NF-κB, Notch, TGF-β/Smad, HIF-1α/VEGF, and maintain the balance of inflammatory interactions.
, inhibit oxidative stress and regulate abnormal glucose metabolism
.

the result shows

In addition, signaling pathways such as Janus kinase signal transducer and activator of transcription (JAK/STAT) and toll-like receptor (TLR) are closely related to diabetes
.

However, there are relatively few studies on the above pathways in traditional Chinese medicine, which will be one of the directions that need to be further explored in the future

Signaling pathways such as Janus kinase signal transducer and activator of transcription (JAK/STAT) and toll-like receptor (TLR) are closely related to diabetes

The signaling pathway of traditional Chinese medicine to promote the healing of diabetic wounds:

To sum up, natural products (including herbal medicines) are the most precious wealth left to us by nature and have played an indelible role in the history of human health development
.

The study clarified the mechanism and potential of traditional Chinese medicine in promoting the healing of diabetic wounds from the perspective of signaling pathways

The study clarified the mechanism and potential of traditional Chinese medicine in promoting the healing of diabetic wounds from the perspective of signaling pathways

Original: Zhou X, Guo Y, Yang K, Liu P, Wang J.

Original: Zhou X, Guo Y, Yang K, Liu P, Wang J.
The signaling pathways of traditional Chinese medicine in promoting diabetic wound healing.
J Ethnopharmacol.
2022 Jan 10;282:114662.
doi: 10.
1016/j.
jep.
2021.
114662 .
Epub 2021 Sep 20.
PMID: 34555452.
Leave a comment here